Cannabis Extract Shows Anti-Inflammatory and Antidepressant-Like Effects in Mice—But Human Relevance Remains Unproven
Cannabis sativa L. leaf extract reduced the immobility time in the forced swimming test and increased sucrose preference in the LPS model, without affecting the total distance and time in the center in the open field test.
Cannabidiol reduces the latency for the behavioral effect of escitalopram in chronically stressed male mice: involvement of NAPE-PLD expressed in parvalbumin-positive interneurons and the prefrontal cortex.
A preclinical study found that CBD accelerates antidepressant effects and enhances SSRI response at lower doses in stressed mice. While promising, these animal findings require clinical validation before informing human treatment protocols.
Unveiling the Complex Interplay: Sudden Emergence of First-Rank Schneiderian Symptoms Following TMS in a Patient With Severe Depression and Complex Trauma.
A case report documents synthetic cannabinoid induced psychosis developing after TMS treatment in a depressed patient. This highlights the need for comprehensive substance screening before neuromodulation therapies. Synthetic cannabinoids pose…
Medicinal Cannabis Doesn’t Help Anxiety, Depression, or PTSD, Huge Review Finds
A large systematic review found limited evidence for cannabis in treating mental health disorders such as anxiety, depression, and PTSD. This challenges the widespread use of medicinal cannabis for these psychiatric conditions. Clinicians should…
Clinics Handing Out Medicinal Cannabis for Anxiety and Depression Despite ‘No Evidence’ It Works
Clinics handing out medicinal cannabis anxiety treatments are increasing despite limited evidence of effectiveness. This trend raises important questions for clinicians and patients alike. Monitoring emerging research is essential for informed clinical…
Largest-ever Psychedelics Study Could Advance Use in Treating Mental Health Disorders
The largest psychedelic research mental health study marks a critical step toward evidence-based psychiatric care. This large-scale study aims to identify which patients benefit most from psychedelics. It could establish standardized protocols for…
5 Essential Breakthroughs in Cannabis Neuromodulation
5 Essential Breakthroughs in Cannabis Neuromodulation Imagine a world where a simple plant could revolutionize the way we treat some of the most challenging health issues, from anxiety and depression to Alzheimer's and Parkinson's disease.…