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Combined Impact of Cannabinoids and Cocaine on Outcomes of Trauma Patients.
A large retrospective study of trauma patients found no significant difference in hospital mortality between those testing positive for cannabinoids cocaine trauma mortality outcomes versus cannabinoids alone. While this challenges assumptions about…
A relational agent for treating substance use in adults: A randomized controlled trial with a psychoeducational comparator.
A randomized controlled trial demonstrates that a smartphone-based digital intervention for substance use disorders achieved greater reductions in substance use occasions compared to psychoeducational content alone. This research supports the potential…
Cannabis & Dental Care
Clinical Relevance #62 Emerging but Limited Evidence Mechanistic promise exists, but clinical translation remains early and uncertain. Clinical Insight Cannabis in dentistry is biologically plausible but clinically immature. The key risk is…
Baseline characteristics and feasibility of clinical outcome measures in CDKL5 deficiency disorder: The CANDID observational study.
A large observational study successfully validates clinical outcome measures in CDKL5 deficiency disorder, revealing severe early-onset epilepsy with median seizure onset at 1.5 months. This research establishes crucial infrastructure for evaluating…
Sex-Dependent Cannabis Withdrawal Pain and Circulating Cannabinoids
This study highlights cannabis withdrawal pain sex differences linked to circulating cannabinoid levels. Men and women experience distinct acute pain responses during brief abstinence. Understanding these differences is crucial for personalized cannabis…
The effect of hemp product consumption on blood fatty acid profiles and cardiovascular disease risk factors: results of a randomized, double-blind, crossover clinical trial.
A randomized crossover trial demonstrates that hemp seeds cardiovascular benefits include significant improvements in blood fatty acid profiles. This clinical research provides evidence-based support for hemp seeds as a nutritional intervention for…
CAN-PACT: Advancing Psychedelic-Assisted Therapy in Oncology Supportive Care
The CAN-PACT initiative focuses on psychedelic-assisted therapy oncology supportive care for cancer patients experiencing demoralization syndrome. This multi-phase program emphasizes training, safety, and research infrastructure. It aims to establish…
Reductions in Cigarette and Cannabis Use During Alcohol Treatment
This study reveals polysubstance use alcohol treatment patterns with significant cigarette reductions and a biphasic cannabis use trend. Participants in an alcohol use disorder trial showed early cannabis decreases followed by later increases.…
Effects of Prescribed Medical Cannabis on Driving: Study Protocol Analysis
Australian researchers have developed a medical cannabis driving safety protocol to assess real-world driving performance in patients using prescribed THC. This two-phase trial aims to provide critical evidence on driving safety for medical cannabis…
Regulatory Digest 2026-03-10
Regulatory updates (higher clinical relevance)