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CBD and THC Interaction: Meta-Analysis Reveals Impact on Plasma Levels
A meta-analysis explores how CBD influences THC plasma levels, revealing increased bioavailability and prolonged exposure. The study shows co-administration of CBD with THC significantly elevates AUC for both THC and its metabolite 11-OH-THC. These…
Cannabis, CBD, and Insomnia: What Causes Sleeplessness and What the Evidence Supports
CBD for insomnia is sold with far more confidence than the trial evidence supports, and a physician should say so plainly. Controlled studies of cannabidiol, THC, and cannabinol in diagnosed insomnia have mostly missed their primary endpoints while…
CBD and Prostate Cancer: Cell and Mouse Studies Show Activity, and the One Human Trial Tested Only Safety
Research on CBD and prostate cancer is preclinical: cannabidiol induces apoptosis in PC3 cells and slowed tumor growth in mice, reported by two independent laboratories. The only completed human study gave pharmaceutical cannabidiol to 21 men with rising…
Two Molecules, Two Routes: How the Body Handles THC and CBD Differently
THC and CBD metabolism run through overlapping liver enzymes to entirely different products, with THC oxidized principally by CYP2C9 to an active metabolite and CBD handled mainly by CYP3A4 and CYP2C19 into a family of hydroxylated compounds. Their…
THC, CBD, and Cytokine Storms: A Strong Laboratory Signal and One Negative Human Trial
Research on cannabinoids and cytokine storm is real and largely preclinical: cannabidiol and THC reduce inflammatory cytokine output in immune cells and in mouse models of sepsis and lung inflammation. The single randomized placebo-controlled trial in…
Cannabis Science Digest: Driving Behavior, CBD Use, and Emotional Processing
Cannabis science digest findings describe driving behavior, public CBD use, and emotional processing after short abstinence. The studies offer human evidence signals while retaining important simulator, survey, and pilot-design limits. None proves a…
CED Cannabis Science Digest: CBD and Macrophage Inflammation, Texas Compassionate Use Access
CBD macrophage inflammation: A controlled human cell-culture study found CBD selectively reduced part of the inflammatory response in lipid-stressed macrophages, and a separate policy analysis argues Texas should add dialysis patients as a qualifying…
Limited Evidence for Topical CBD Pain Relief According to Recent Study
Recent research challenges widespread claims about topical CBD for pain relief, finding insufficient evidence to support its effectiveness for musculoskeletal soreness. While topical CBD for pain has gained popularity among consumers, clinical trials…
The Use of Cannabidiol Suppositories for Sexual Pain
A new clinical trial is investigating cannabidiol suppositories sexual pain treatment research to address the significant unmet need in sexual health medicine. The study evaluates topical CBD delivery for reducing intimate discomfort over a one-month…
Demographic features, health status, and behavioral changes associated with cannabidiol use in the Dog Aging Project.
The Dog Aging Project's survey of over 20,000 dog owners provides the first large-scale analysis of CBD use patterns in companion dogs study, revealing how owner demographics and perceived health needs drive cannabidiol administration decisions. While…