The Use of Cannabidiol Suppositories for Sexual Pain
A new clinical trial is investigating cannabidiol suppositories sexual pain treatment research to address the significant unmet need in sexual health medicine. The study evaluates topical CBD delivery for reducing intimate discomfort over a one-month…
Demographic features, health status, and behavioral changes associated with cannabidiol use in the Dog Aging Project.
The Dog Aging Project's survey of over 20,000 dog owners provides the first large-scale analysis of CBD use patterns in companion dogs study, revealing how owner demographics and perceived health needs drive cannabidiol administration decisions. While…
Effects and mechanisms of cannabidiol in attenuating orofacial inflammatory pain and ameliorating pain-related affective deficits.
A new preclinical study found that cannabidiol orofacial inflammatory pain study showed promising results in reducing both sensory and emotional aspects of facial pain in laboratory mice. While encouraging for future research directions, these animal…
Cannabidiol reduces the latency for the behavioral effect of escitalopram in chronically stressed male mice: involvement of NAPE-PLD expressed in parvalbumin-positive interneurons and the prefrontal cortex.
A preclinical study found that CBD accelerates antidepressant effects and enhances SSRI response at lower doses in stressed mice. While promising, these animal findings require clinical validation before informing human treatment protocols.
Modulating the endocannabinoid system in alcohol use disorder: A translational systematic review and meta-analysis of preclinical and human studies.
A comprehensive systematic review examining CBD alcohol use disorder treatment potential found that CBD consistently reduced alcohol consumption in preclinical studies. However, human clinical data remains insufficient to support treatment…
Highly purified cannabidiol (CBD) in CDKL5 deficiency disorder (CDD): Open-label prospective study.
A new open-label study examining CBD for CDKL5 deficiency disorder treatment found 89% of patients continued therapy for 12 months. While retention rates suggest tolerability, efficacy data remains limited in this rare developmental epilepsy condition.
A single dose of cannabidiol increases ad libitum energy intake in healthy adults but does not affect postprandial glucose or lipid metabolism.
A randomized controlled trial found that CBD appetite effects included a significant 193-calorie increase in food intake among healthy adults. This CBD appetite effects study challenges assumptions about cannabidiol's impact on eating behavior and…
Cannabidiol in Epilepsy: Restoring Locomotion and Seizure Control.
A comprehensive review demonstrates CBD's potential for seizure control while maintaining motor function in epilepsy models. This motor-sparing profile of CBD distinguishes it from traditional antiepileptics that often impair movement and coordination.…
Synergistic Neuroimmune Modulation by Cannabidiol and Probiotics for Therapeutic Advancement in CNS Disorders: A Systematic Review.
New systematic review identifies mechanistic pathways for CBD probiotics gut brain axis synergy in neurological disorders. While biologically plausible, combination therapy effectiveness requires controlled clinical trials before therapeutic…
Cannabidiol as a Prophylactic Agent Against Glioblastoma Growth: A Preclinical Investigation.
A new preclinical study demonstrates that CBD glioblastoma prevention may be possible through extended pretreatment in mice. While promising, this early research requires extensive human studies before any clinical applications. Dr. Caplan explains what…