Why Averages Fail Palliative Cannabis Patients – A New Framework
Randomized controlled trials often fail to capture what palliative care cannabis patients actually experience. A new contextual effectiveness framework argues that averaging subjective outcomes obscures genuine individual benefit. This Evidence Brief…
The Limits of Averages: A Framework for Contextual Effectiveness in Palliative Care Medicinal Cannabis Research.
This article explores contextual effectiveness in palliative care cannabis research, addressing why patient-reported benefits often differ from clinical trial averages. It highlights the importance of individualized treatment outcomes in medicinal…
Assessing Evoked and Spontaneous Pain with Gabapentin and CB2 Receptor Activation
This study investigates neuropathic pain CB2 receptor activation and gabapentin effects on evoked and spontaneous pain. Using a spared nerve injury model, researchers compared pain responses in rats. Findings highlight potential cannabinoid mechanisms…
Associations Between Cannabis Use and Inflammatory Biomarkers Among People with HIV
This study investigates cannabis use inflammatory biomarkers among people with HIV to assess potential immune effects. Researchers analyzed 13 plasma biomarkers in 532 virally suppressed patients. Findings inform clinical discussions on cannabis use and…
Unveiling Neurological Benefits: Hemp Extracts in Neurological Disorders
Neurological disorders such as epilepsy, Alzheimer's disease, Parkinson's disease, and multiple sclerosis present significant global health care challenges. This review highlights hemp extract neurological disorders benefits, focusing on hemp leaf,…
A Randomized Trial on Topical Cannabis Balms for AIMSS
This randomized trial evaluates topical cannabis balms AIMSS clinical trial feasibility and tolerability in postmenopausal breast cancer survivors. The study compares CBD and THC balms for joint pain relief. Results provide preliminary insights into…
Regular Cannabis Use and Its Impact on Endocannabinoid System Tolerance
This pilot study examines endocannabinoid system cannabis tolerance in regular users and its impact on exercise-induced anandamide response. Chronic cannabis use may blunt natural endocannabinoid activity, affecting mood and pain regulation during…
Systematic Review: Medical Cannabis for Diabetic Peripheral Neuropathy
This systematic review evaluated medical cannabis diabetic neuropathy interventions in randomized controlled trials. Evidence shows potential pain relief benefits for diabetic peripheral neuropathy. The review highlights cautious optimism for cannabis…
Oral Consumption of Cannabidiol During Pregnancy Alters Behavior in Mouse Offspring
Pregnancy CBD neurodevelopment safety is critical as this mouse study shows oral cannabidiol alters offspring behavior. Prenatal CBD exposure caused sex-specific neurodevelopmental effects. These findings highlight potential risks of CBD use during…