How Cannabis Interacts With the Aging Brain and Its Endocannabinoid System
Cannabis aging brain endocannabinoid system research shows that baseline endocannabinoid tone declines with age. This study demonstrates that cannabis produces larger proportional increases in key compounds like anandamide in older adults. These findings…
Oral Cannabidiol in the Treatment of Myofascial Pain Disorder of the Temporomandibular Region: A Placebo-Controlled Randomized Clinical Trial.
The oral cannabidiol myofascial pain disorder trial investigates CBD's efficacy for temporomandibular pain. This placebo-controlled randomized clinical trial evaluates pain reduction and jaw function. Results could inform future treatment options for…
The Limits of Averages: A Framework for Contextual Effectiveness in Palliative Care Medicinal Cannabis Research.
This article explores contextual effectiveness in palliative care cannabis research, addressing why patient-reported benefits often differ from clinical trial averages. It highlights the importance of individualized treatment outcomes in medicinal…
Analgesic Effect of Cannabinoids for Fibromyalgia: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis examines cannabinoid analgesic effects fibromyalgia patients experience. It provides evidence on cannabinoids as a potential treatment for fibromyalgia pain. The study highlights the importance of considering…
Efficacy and Safety of Cannabinoids for Neuropsychiatric Symptoms of Dementia: A Systematic Review with Meta-analysis.
This systematic review evaluates cannabinoid efficacy dementia symptoms including agitation, anxiety, and depression in patients with dementia. It highlights cannabinoids as a potential safer alternative to traditional antipsychotics. The study…
Comparative Pharmacokinetics and Safety of Cannabidiol in a Powder Formulation, CBtru
CBD pharmacokinetics powder formulation offers improved bioavailability compared to traditional oil-based CBD. This study evaluates the safety and absorption differences of CBtru. Understanding these factors is essential for optimizing cannabidiol dosing.
Prepregnancy Care and Counseling: A Review.
Prepregnancy care counseling is essential to optimize maternal health before conception. This review highlights the importance of cannabis cessation alongside other substance use interventions. Effective prepregnancy care counseling improves outcomes for…
Ketamine Addiction Following Single Sub-Anaesthetic Treatment: Case Report
This case report highlights ketamine addiction risk assessment following a single sub-anaesthetic ketamine treatment. A 25-year-old woman with psychiatric comorbidities developed addiction despite controlled clinical use. The report underscores the need…
A Physician’s Interpretation of a 2,500-Study Review
Medical cannabis evidence remains more limited than many patients expect. A large JAMA review of over 2,500 studies highlights where clinical support exists and where it does not. This analysis clarifies what current medical cannabis evidence can…
CBD for anxiety in Brain Tumors patients
CBD for anxiety in brain tumor patients is an appealing idea, but this early-terminated randomized crossover trial did not show benefit over placebo. The study also found no clear improvement in depressive symptoms, despite using high-purity oral CBD at…
