Mechanistic Pathways Linking Cannabidiol, Hemp Seed Oil and Black Sesame Oil in Hyperarousal Insomnia: A Narrative Review.
A narrative review examines how CBD hyperarousal insomnia mechanistic pathways may involve endocannabinoid, inflammatory, and autonomic system modulation. While mechanistically plausible, this theoretical framework requires clinical validation before…
Cannabidiol-Loaded Mucoadhesive PLGA Nanosphere-Chitosan Hydrogel Patch for Oral Therapeutic Applications.
Researchers developed a CBD hydrogel patch with sustained release properties that achieved over 90% drug release within 96 hours in laboratory testing. While the CBD hydrogel patch sustained release technology shows promise for addressing bioavailability…
Cannabidiol in Epilepsy: Restoring Locomotion and Seizure Control
A comprehensive review demonstrates CBD's potential for seizure control while maintaining motor function in epilepsy models. This motor-sparing profile of CBD distinguishes it from traditional antiepileptics that often impair movement and coordination.…
Synergistic Neuroimmune Modulation by Cannabidiol and Probiotics for Therapeutic Advancement in CNS Disorders: A Systematic Review.
New systematic review identifies mechanistic pathways for CBD probiotics gut brain axis synergy in neurological disorders. While biologically plausible, combination therapy effectiveness requires controlled clinical trials before therapeutic…
Quasi-randomization to Cannabinoid Condition in Studies of US Legal Market Cannabis: Characteristics of Accepters Versus Decliners of Condition Assignment.
A methodology study examining cannabis research selection bias found systematic differences between participants who accept versus decline assigned cannabis conditions. This quasi-randomization research provides crucial insights for interpreting legal…
Cannabidiol as a Prophylactic Agent Against Glioblastoma Growth: A Preclinical Investigation.
A new preclinical study demonstrates that CBD glioblastoma prevention may be possible through extended pretreatment in mice. While promising, this early research requires extensive human studies before any clinical applications. Dr. Caplan explains what…
Muscular Dystrophy Muscle Preservation: A Comparative Systematic Review of Exercise and Cannabidiol (CBD) Interventions.
A new systematic review comparing exercise therapy muscular dystrophy muscle preservation strategies finds that exercise interventions demonstrate consistent functional benefits while cannabidiol evidence remains limited to preclinical studies. This…
Plasma cannabinoid pharmacokinetics following the inhalation of vaporised cannabis with and without cannabidiol.
A randomized controlled trial found that CBD effects on THC plasma concentrations were minimal when cannabis was vaporized, challenging assumptions about CBD reducing THC bioavailability. The study showed similar cannabinoid pharmacokinetics between…
Regular cannabinoid use and inflammatory biomarkers: Systematic review and hierarchical meta-analysis.
A comprehensive systematic review of cannabis inflammatory biomarkers found associations with anti-inflammatory markers in observational studies. However, the clinical significance of these laboratory changes remains uncertain, and the predominance of…
Cannabis & Dental Care
Clinical Relevance #62 Emerging but Limited Evidence Mechanistic promise exists, but clinical translation remains early and uncertain. Clinical Insight Cannabis in dentistry is biologically plausible but clinically immature. The key risk is…
