Randomized and Blind Evaluation of the Efficacy of a Full-Spectrum Oral
This randomized and blind evaluation investigates the efficacy of full-spectrum oral cannabis extract for chronic osteoarthritis pain. The study provides clinical evidence on pain relief potential. Results highlight the importance of full-spectrum oral…
Understanding Neurotransmitter Systems in Alzheimer’s Disease
Neurotransmitter systems Alzheimer's disease dysfunction plays a key role in cognitive decline. Multiple systems including cholinergic, glutamatergic, and GABAergic are affected. Understanding these systems helps explain treatment challenges.
Endocannabinoid Enhancement via MAGL Inhibition in CDKL5 Deficiency: Selective Cellular Benefits and Domain-Specific Functional Effects in Adult
This study investigates the endocannabinoid system CDKL5 deficiency and the effects of MAGL inhibition. Enhancing endogenous 2-AG signaling shows selective cellular benefits. These findings highlight potential domain-specific functional improvements in…
Cannabis Use Patterns in First Episode Psychosis and Schizophrenia: A Scoping Review and Case Series
Cannabis use patterns schizophrenia are critical to understanding psychosis and schizophrenia development. This review highlights inconsistent measurement methods in current research. Better assessment tools are needed for clinical practice in this…
THC and CBD Induce Cell Death via Heme Oxygenase-1 in Skin Cancer Cells
Cannabinoids skin cancer research reveals that THC and CBD induce cell death through heme oxygenase-1 pathways. This study highlights mitochondrial dysfunction in melanoma and squamous carcinoma cells. These findings provide early mechanistic insight…
Relationship of Ethanol, Cannabinoids, Benzodiazepines, and Opioids to Serious Injuries from Falls in Adults Aged 55 and Older
The falls geriatric cannabis safety cohort study examines the role of ethanol, cannabinoids, benzodiazepines, and opioids in serious injuries from falls in adults aged 55 and older. This research provides objective toxicological data to better understand…
Medicinal Cannabis Prescription Before Psychiatric Admission: Audit Results
This study investigates medicinal cannabis psychiatric inpatient use through a retrospective observational audit. It highlights prescription patterns and safety concerns in psychiatric populations. The findings provide important baseline data for…
Substance Use in Supportive Oncology and Its Impact on Clinical Outcomes and Care
Substance use in supportive oncology significantly influences clinical outcomes and treatment adherence. This review highlights the impact of alcohol, tobacco, cannabis, and opioids on cancer care. Understanding substance use patterns is essential for…
Loss of dystrophin reduces CB1 receptor expression and endocannabinoid-dependent synaptic plasticity in the cerebellar cortex.
Dystrophin endocannabinoid system disruption reduces CB1 receptor expression in the cerebellar cortex. This affects endocannabinoid-dependent synaptic plasticity, relevant to Duchenne Muscular Dystrophy. Understanding this mechanism may inform future…
Phase 2 Open-Label INSPIRE Trial on Transdermal CBD Gel in 22q11.2 Deletion Syndrome
The INSPIRE trial investigates transdermal cannabidiol gel children with 22q11.2 deletion syndrome to assess safety and tolerability. This phase 2 open-label study provides preliminary data on CBD gel use in pediatric neurodevelopmental disorders.…
