# What’s the science behind a runner’s high? > **Author:** Benjamin Caplan, MD (ABFM Board Certified, MA Lic. #240562, NPI: 1962722637) > **Publisher:** CED Clinic (https://cedclinic.com) > **Canonical URL:** https://cedclinic.com/whats-the-science-behind-a-runners-high/ > **Published:** 2026-08-31T17:28:48-04:00 | **Last Modified / Clinically Audited:** 2026-09-28T10:40:46-04:00 > **Clinical Summary:** Explore how anandamide, a natural 'feel-good' chemical from the endocannabinoid system, contributes to the runner's high, offering insights for pain management. --- ✦ New CED Clinical Relevance #77 Strong Clinical Relevance High-quality evidence with meaningful patient or clinical significance. NeurologyAnxietyMental HealthResearchDosingSafetyPolicy Why This Matters This article matters for clinicians and their patients as it sheds light on the science behind a runner’s high, which can provide insights into the body’s natural response to physical exercise. The discovery of anandamide, a brain chemical produced by the [endocannabinoid system](https://cedclinic.com/endocannabinoid-system-fear-extinction/), contributes to feelings of euphoria during exercise and may have potential implications for managing pain and mood disorders in [clinical practice](https://cedclinic.com/cannabis-reproductive-health-women-clinical-evidence/). Understanding the mechanisms behind a runner’s high could lead to new treatment strategies for various health conditions. Clinical Summary This article discusses the role of anandamide, a naturally occurring “feel-good” chemical produced by the [endocannabinoid system](https://cedclinic.com/endocannabinoid-system-fear-extinction/), in inducing the runner’s high. Anandamide interacts with the body’s [cannabinoid receptors](https://cedclinic.com/citral-cannabinoid-receptor-2-activation-pain-relief/) to reduce pain and increase pleasure during physical exercise. For clinicians, understanding the mechanisms behind the runner’s high may provide insights into potential therapeutic applications for managing pain and improving mood in patients. Dr. Caplan’s Take “As a seasoned family physician specializing in [cannabis medicine](https://cedclinic.com/essential-oils-industrial-hemp-antimicrobial-benefits/), I find the recent research on the ‘runner’s high’ particularly intriguing. The role of anandamide, a key player within our [endocannabinoid system](https://cedclinic.com/endocannabinoid-system-fear-extinction/), in inducing feelings of euphoria and reducing pain is captivating. However, while these findings are promising, it’s crucial to emphasize that more human-based, peer-reviewed studies are needed to fully understand the mechanisms at play and potential therapeutic applications.” Clinical Perspective 🏃‍♂️ Embracing the science behind a runner’s high: Anandamide, a key endocannabinoid, is recognized as one of the brain’s natural “feel-good” chemicals. Its production during exercise contributes to the euphoric sensation often experienced by runners. However, it’s crucial to acknowledge that the complex interplay between anandamide and other neurotransmitters can influence this response. In [clinical practice](https://cedclinic.com/cannabis-reproductive-health-women-clinical-evidence/), understanding the role of endocannabinoids in exercise-induced mood enhancement may provide insights for managing pain and improving mental health outcomes in patients. Encouraging regular physical activity, while monitoring for potential confounders such as medication interactions or individual sensitivity, could offer a holistic approach to [patient care](https://cedclinic.com/cannabis-cardiovascular-risk-impact/). 💬 Join the Conversation Have a question about how this applies to your situation? [Ask Dr. Caplan →](https://benjamincaplan.com/ask-dr-caplan) Want to discuss this topic with other patients and caregivers? [Join the forum discussion →](https://cedclinic.com/interact/discussion-forums/forum/medical-illness/) Have thoughts on this? 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