# Use of Oral Semaglutide and Associated Clinical Outcomes in Thai Patients With Diabetes > **Author:** Benjamin Caplan, MD (ABFM Board Certified, MA Lic. #240562, NPI: 1962722637) > **Publisher:** CED Clinic (https://cedclinic.com) > **Canonical URL:** https://cedclinic.com/use-of-oral-semaglutide-and-associated-clinical-outcomes-in-thai-patients-with-t/ > **Published:** 2026-06-03T18:58:12-04:00 | **Last Modified / Clinically Audited:** 2026-09-28T10:53:18-04:00 > **Clinical Summary:** Discover how oral semaglutide improved HbA1c and weight in Thai patients with type 2 diabetes over 26 weeks. --- ## Oral Semaglutide in Type 2 Diabetes: Real-World Results From Thailand GLP-1 Receptor Agonist Type 2 Diabetes Glycaemic Control Weight Reduction Real-World Evidence What You Will Learn From This Review: - How oral semaglutide performed on HbA1c and body weight in Thai patients with type 2 diabetes over 26 weeks in routine clinical care - What proportion of real-world patients reached the HbA1c target of less than 7% and a composite glycaemic-plus-weight outcome - How safety data, including severe hypoglycaemia, compared to other regional and Western real-world cohorts - Where this evidence is strong and where a careful clinician should remain cautious **TL;DR: In 195 Thai adults with type 2 diabetes receiving oral semaglutide predominantly as add-on therapy, HbA1c fell by an estimated 0.7 percentage points and body weight by an estimated 4.4 kg over 26 weeks, with 75.9% of completers reaching HbA1c below 7% and no severe hypoglycaemia recorded.** STUDY DESIGN: Retrospective Multi-Centre Cohort (Real-World Evidence) ## Abstract **Aims:** The REALISED study assessed the clinical outcomes associated with oral semaglutide use in Thai patients with type 2 diabetes (T2D) in real-world clinical settings. **Materials and Methods:** This retrospective, multi-centre cohort study included 195 patients with T2D initiating oral semaglutide between April 2022 and December 2023. Eligible participants had no prior injectable therapy and completed at least 26 weeks of treatment. The primary endpoint was the change in HbA1c from baseline to the end-of-study (EoS, Week 26); Week 52 outcomes were exploratory. Secondary endpoints included changes in body weight and the proportion achieving HbA1c less than 7%. Severe hypoglycaemia was the safety endpoint. A post hoc composite endpoint combined HbA1c less than 7% with at least 3% weight loss. Analyses used a mixed model for repeated measures and descriptive statistics. **Results:** Oral semaglutide was predominantly used as add-on therapy (190/195 [97.4%]). Mean HbA1c decreased by -0.7% (95% CI: -0.9 to -0.5; p<0.0001), and mean body weight decreased by -4.3 kg (95% CI: -5.5 to -3.2; p<0.0001). At EoS, 75.9% (117/154) achieved HbA1c less than 7%, and 57.7% (71/123) met the composite endpoint. No severe hypoglycaemia occurred. Dose escalation from 3 mg to 14 mg was observed in 53.2% by Week 26 and 70.4% by Week 52. **Conclusions:** The REALISED study provides the first real-world evidence of oral semaglutide use in Thai patients with T2D, demonstrating significant improvements in glycaemic control and weight reduction across routine care settings. **Source:** Wannachalee T, Anthanont P, Sirisreetreerux S, et al. Use of Oral Semaglutide and Associated Clinical Outcomes in Thai Patients With Type 2 Diabetes: Real-World Evidence From the REALISED Study. *Diabetes, Obesity and Metabolism.* 2026;28:5058–5067. **DOI:** [https://doi.org/10.1111/dom.70701](https://doi.org/10.1111/dom.70701) **Open Access:** Yes (Creative Commons Attribution-NonCommercial-NoDerivs) ## Study at a Glance Design Retrospective, single-arm, multi-centre cohort; routine clinical records from four university hospitals in Thailand Population Thai adults (age 18+) with confirmed T2D, no prior injectable therapy; n = 195 (full analysis set) Intervention Oral semaglutide (predominantly 3 mg start with titration to 7 mg and 14 mg), used as add-on therapy in 97.4% Primary Endpoint Change in HbA1c from baseline to Week 26 (end-of-study, EoS) Key Finding Estimated HbA1c reduction: -0.7 percentage points (95% CI: -0.9 to -0.5; p<0.0001); weight: -4.4 kg (95% CI: -5.5 to -3.3; p<0.0001); 75.9% of completers reached HbA1c <7%; no severe hypoglycaemia ## Study Snapshot: Key Statistics Outcome Estimated Change (Model-Based) 95% CI p-value HbA1c, absolute change (%-points) -0.7 -0.9 to -0.5 <0.0001 HbA1c, relative change (%) -9.8% -12.0 to -7.5 <0.0001 Body weight, absolute change (kg) -4.4 -5.5 to -3.3 <0.0001 Body weight, relative change (%) -5.3% -6.5 to -4.0 <0.0001 Proportion achieving HbA1c <7% at EoS 75.9% (117/154) N/A N/A Composite: HbA1c <7% + BW reduction ≥3% 57.7% (71/123) N/A N/A Severe hypoglycaemia 0 events N/A N/A Treatment discontinuation by EoS 4.1% (8/195) N/A N/A ## Full Study Facts Authors Wannachalee T, Anthanont P, Sirisreetreerux S, Nayak G, Chumchujan W, Iamsudjai Y, Buranapin S Journal *Diabetes, Obesity and Metabolism* Year 2026 DOI 10.1111/dom.70701 Design Retrospective, single-arm, multi-centre cohort (real-world evidence); four university hospitals in Bangkok, Pathum Thani, and Chiang Mai, Thailand N (Full Analysis Set) 195 Intervention Oral semaglutide; 92.3% initiated at 3 mg with titration per standard protocol; used predominantly as add-on to existing oral agents Comparator None (single-arm observational study) Primary Endpoint Change in HbA1c (%-points) from baseline to Week 26 Key Results HbA1c: -0.7%-points (95% CI: -0.9 to -0.5; p<0.0001); body weight: -4.4 kg (95% CI: -5.5 to -3.3; p<0.0001); HbA1c <7% achieved in 75.9% of completers; composite endpoint (HbA1c <7% + BW reduction ≥3%) met in 57.7% Adverse Events No severe hypoglycaemia throughout observation (including Week 52); overall discontinuation 4.1% by EoS; one discontinuation attributed to GI intolerability Funding Novo Nordisk (medical writing support) Conflicts of Interest G. Nayak, W. Chumchujan, and Y. Iamsudjai are Novo Nordisk employees. S. Buranapin received a research grant from Novo Nordisk. T. Wannachalee and P. Anthanont declare no conflicts of interest. ## What Researchers Actually Did Between April 2022 and December 2023, investigators at four Thai university hospitals identified adult patients with confirmed type 2 diabetes who had initiated oral semaglutide and had no prior exposure to injectable glucose-lowering agents (insulin or GLP-1 receptor agonists). From 222 screened patients, 27 were excluded for missing baseline HbA1c, treatment interruptions exceeding two weeks, prior injectable use, or other protocol deviations, leaving 195 in the full analysis set. Baseline HbA1c was the most recent value within 12 weeks before initiation. The primary assessment was defined as the HbA1c measurement closest to Week 26 (within a plus-or-minus six-week window), consistent with standard six-month clinical follow-up. An optional extended observation period extended to Week 52 for patients who continued routine care; 72 patients had HbA1c data available at that time point. Changes in HbA1c and body weight were estimated using a three-level mixed model for repeated measures (MMRM), incorporating linear and quadratic time since initiation, time-varying semaglutide dose (3, 7, or 14 mg), baseline HbA1c or weight, and random intercepts for both site and patient, with random slopes for time. Missing post-baseline data were handled under the missing-at-random assumption. Sensitivity analyses assessed EoS completers, patients with baseline HbA1c at or above 7%, those with baseline BMI at or above 25 kg/m2, and patients with stable background antidiabetic regimens. A post hoc composite endpoint, defined as HbA1c below 7% combined with at least 3% reduction in body weight, was applied to 123 participants with complete data for both measures. ## Key Findings: Primary Outcomes - **HbA1c reduction (model-based, FAS, n=195):** Estimated mean change from baseline to Week 26 was -0.7 percentage points (95% CI: -0.9 to -0.5; p<0.0001); relative change was -9.8% (95% CI: -12.0 to -7.5; p<0.0001). - **Observed HbA1c change in completers:** Mean observed reduction was -1.0 percentage points (SD 1.2) among the 154 participants with EoS data, which is numerically larger than the model-based estimate, reflecting the difference between observed data and MMRM-adjusted estimates across all time points. - **Consistency across sensitivity analyses:** Comparable HbA1c reductions were observed in EoS completers (n=154), participants with baseline HbA1c at or above 7% (n=123), and those with stable background antidiabetic medications (n=70). - **On-treatment analysis:** Estimated change was -0.7 percentage points (95% CI: -0.9 to -0.5; p<0.0001), consistent with the in-study result. ## Key Findings: Secondary Outcomes and Subgroup Analyses ### Body Weight - Estimated mean body weight reduction (FAS, n=194) at EoS: -4.4 kg (95% CI: -5.5 to -3.3; p<0.0001), corresponding to -5.3% relative decrease (95% CI: -6.5% to -4.0%; p<0.0001). - On-treatment analysis: -4.6 kg (95% CI: -5.7 to -3.5; p<0.0001); relative decrease -5.5% (95% CI: -6.8% to -4.2%; p<0.0001). - Results were consistent across EoS completers (n=141), patients with BMI at or above 25 kg/m2 (n=159), and those with stable background regimens (n=70). - At Week 52 (exploratory, n=72), observed body weight reduction was approximately -4.7 kg, within the range reported in PIONEER REAL studies. ### HbA1c Target Achievement - Of 154 EoS completers, 117 (75.9%) achieved HbA1c below 7%; 44.4% (52/117) of those had baseline HbA1c at or above 7%, indicating meaningful glycaemic improvement even among those starting above target. ### Composite Endpoint (Post Hoc) - Among 123 participants with complete HbA1c and weight data at baseline and EoS, 71 (57.7%) met the composite of HbA1c below 7% and at least 3% body weight reduction. - Among participants with baseline HbA1c at or above 7% and BMI at or above 25 kg/m2 (n=61), 30 (49.2%) met the composite target. - Among obese participants (BMI at or above 25 kg/m2) with already-adequate glycaemic control (HbA1c below 7%) at baseline (n=43), 32 (74.4%) achieved the composite endpoint at EoS. ### CKD Subgroup (Exploratory) - Participants with normal or mildly decreased kidney function (eGFR at or above 60 mL/min/1.73m2; n=163): HbA1c reduction -0.9 percentage points (95% CI: -1.0 to -0.8; p<0.0001); weight reduction -4.3 kg (95% CI: -5.2 to -3.5; p<0.0001). - Participants with CKD Stage 3 or higher (n=25): HbA1c reduction -0.8 percentage points (95% CI: -1.1 to -0.6; p<0.0001); weight reduction -3.7 kg (95% CI: -6.9 to -0.5; p=0.024). The CKD subgroup analysis is underpowered and should be interpreted with caution, as the authors themselves note. ### Dose Titration Patterns - 92.3% of participants (180/195) initiated at 3 mg; by Week 26, 59.6% of those initiating at 3 mg had escalated to 14 mg; by Week 52, 70.4% of the overall cohort were on 14 mg; no participants continued on 3 mg at Week 52. ### Concomitant Medication Changes - Sulphonylurea use declined from 35.4% at baseline to approximately 22% by EoS; thiazolidinedione use declined from 26.7% to approximately 18%. The authors suggest this may have contributed to observed weight loss, though no formal analysis quantified this contribution. ## Adverse Events and Safety Profile The safety endpoint was defined narrowly as severe hypoglycaemia. No severe hypoglycaemia events were recorded from treatment initiation through Week 52, despite approximately 55% of participants concurrently using sulphonylureas or other insulin secretagogues at baseline. The authors attribute this to the glucose-dependent mechanism of GLP-1 receptor agonists, which attenuates insulin secretion at euglycaemia. Overall, 8 of 195 participants (4.1%) discontinued oral semaglutide by EoS. Among those who discontinued, three were transitioned to subcutaneous semaglutide, one was attributed to GI intolerability, three were due to change in treatment strategy, and four were for unspecified other reasons. The subsequent treatment status of the remaining five was unknown. This low discontinuation rate compares favourably to the 7% to 12% reported in Japanese and Italian real-world cohorts cited by the authors. The study did not systematically capture non-severe GI adverse events, weight loss-related symptoms, or other tolerability data, which limits the completeness of the safety picture. ## Statistical Approach and Rigor The primary analysis used a three-level MMRM with restricted maximum likelihood estimation. The model incorporated hierarchical clustering (site as a second-level random intercept, patient as a third-level random intercept), random slopes for time, and fixed effects for linear and quadratic time, time-varying semaglutide dose, and baseline values of the respective outcome. An unstructured covariance matrix was applied at the patient level. This approach is appropriate for longitudinal observational data with irregular visit intervals and is consistent with the methods used in the PIONEER clinical trial program. The sample size was powered to detect a mean HbA1c reduction of 0.46 percentage points (SD 1.7) with 90% power, requiring 146 patients with EoS Hb Evidence Watch Reading Tool ### Read This Paper Through Nine Different Lenses The same evidence can produce very different conclusions depending on the question being asked. Explore this study through multiple physician-guided interpretive frameworks. OVERVIEW REALISED study shows oral semaglutide effectively reduces HbA1c and body weight in Thai patients. #### Overview Badge 1: ComprehensiveBadge 2: Real-World DataBadge 3: Significant Outcomes The REALISED study provides real-world evidence of oral semaglutide’s efficacy in Thai patients with type 2 diabetes, demonstrating significant improvements in HbA1c and body weight reduction. Key findings include a mean HbA1c decrease of -0.7 percentage points and a body weight reduction of -4.4 kg over 26 weeks, with no severe hypoglycaemia reported. - Significant improvements in HbA1c and body weight - No severe hypoglycaemia events recorded - High proportion of patients achieved HbA1c below 7% Key Insight Oral semaglutide significantly improved glycemic control and weight in Thai type 2 diabetes patients. #### Patient Takeaway Badge 1: Patient-CentricBadge 2: Real-World ExperienceBadge 3: Safety Assured Patients using oral semaglutide experienced significant reductions in HbA1c and body weight, with no severe hypoglycaemia reported. The study provides real-world evidence that can help patients understand the potential benefits of this treatment option. - Mean HbA1c reduction of -0.7 percentage points - Mean body weight reduction of -4.4 kg - No severe hypoglycaemia events Patient Takeaway Oral semaglutide can effectively manage blood sugar and aid in weight loss without severe [side effects](https://cedclinic.com/cannabis-intoxication-memory-disruption/). #### Clinician’s POV Badge 1: Evidence-BasedBadge 2: Real-World ApplicabilityBadge 3: Safety Data Clinicians can use this study to support the prescription of oral semaglutide for type 2 diabetes management, as it shows significant improvements in HbA1c and body weight. The absence of severe hypoglycaemia adds to its safety profile, making it a viable option for patients. - HbA1c reduction of -0.7 percentage points - Body weight reduction of -4.4 kg - No severe hypoglycaemia reported Clinician Insight Oral semaglutide offers effective glycemic control and [weight management](https://cedclinic.com/cannabis-metabolism-weight-management-science/) with a favorable safety profile. #### A Skeptical Read Badge 1: Critical ViewBadge 2: Real-World EvidenceBadge 3: Safety Considerations While the study shows promising results, skeptics may consider the need for longer-term studies to confirm long-lasting effects. The absence of severe hypoglycaemia is reassuring but further research on non-severe adverse events is needed. - Significant HbA1c and weight reductions - No severe hypoglycaemia reported - Need for longer-term studies Skeptic Insight Oral semaglutide shows promise but requires further long-term research to validate long-lasting benefits. #### Study Critic Badge 1: Critical AnalysisBadge 2: Real-World DataBadge 3: Safety Evaluation Critics may point out the study’s reliance on real-world data, which can introduce variability. The study does not capture non-severe adverse events or weight loss-related symptoms, limiting a complete safety profile. - Real-world evidence with variability - No severe hypoglycaemia but incomplete safety data - Need for more comprehensive safety studies Critic Insight While effective, the study’s reliance on real-world data and limited safety information warrant further scrutiny. #### Compared to Past Research Badge 1: Historical ContextBadge 2: Comparative DataBadge 3: Evolution of Treatment This study builds upon previous research, providing real-world evidence that complements clinical trial data. Compared to other regional and Western studies, the results are consistent with significant improvements in HbA1c and body weight. - Consistent with previous studies - Significant HbA1c and weight reductions - Real-world evidence complements [clinical trials](https://cedclinic.com/endocannabinoid-system-emotional-memory-ptsd-treatment/) Historical Insight The study aligns with past research, showing consistent benefits of oral semaglutide in type 2 diabetes management. #### Practical Considerations Badge 1: Practical ApplicationBadge 2: Real-World RelevanceBadge 3: Clinical Utility Practically, the study supports the use of oral semaglutide in routine clinical care for type 2 diabetes management. The significant HbA1c and body weight reductions make it a practical option for many patients. - Significant HbA1c reduction - Mean body weight reduction - No severe hypoglycaemia Practical Insight Oral semaglutide is practically effective in managing type 2 diabetes with significant benefits and minimal [side effects](https://cedclinic.com/cannabis-intoxication-memory-disruption/). #### Future Directions Badge 1: Future DirectionsBadge 2: Long-Term StudiesBadge 3: Expanded Research Future research should focus on long-term outcomes to confirm the durability of these benefits. Expanded studies could also explore non-severe adverse events and their impact on patient [quality of life](https://cedclinic.com/cannabis-policy-enforcement-february-26-2026/). - Need for long-term studies - Explore non-severe adverse events - Expand research scope Future Insight Further research is needed to confirm long-term benefits and explore additional safety considerations. #### Misreadings & Bad-Faith Takes Badge 1: Common MisunderstandingsBadge 2: Clarification NeededBadge 3: Accurate Interpretation Common misinterpretations include assuming the study applies to all populations without considering genetic and environmental factors. Clarification is needed on the limitations of real-world data, such as variability in patient adherence and treatment duration. - Misunderstandings about population applicability - Limitations of real-world data - Need for clarification Misreading Insight Avoid misinterpreting the study’s results by considering its limitations and applicability to different populations. Have thoughts on this? Share it: [X Share on X](https://twitter.com/intent/tweet?text=Use%20of%20Oral%20Semaglutide%20and%20Associated%20Clinical%20Outcomes%20in%20Thai%20Patients%20With%20T&url=https%3A%2F%2Fcedclinic.com%2Fuse-of-oral-semaglutide-and-associated-clinical-outcomes-in-thai-patients-with-t%2F) [in Share on LinkedIn](https://www.linkedin.com/sharing/share-offsite/?url=https%3A%2F%2Fcedclinic.com%2Fuse-of-oral-semaglutide-and-associated-clinical-outcomes-in-thai-patients-with-t%2F) [🦅 Share on BlueSky](https://bsky.app/intent/compose?text=Use%20of%20Oral%20Semaglutide%20and%20Associated%20Clinical%20Outcomes%20in%20Thai%20Patients%20With%20T%20https%3A%2F%2Fcedclinic.com%2Fuse-of-oral-semaglutide-and-associated-clinical-outcomes-in-thai-patients-with-t%2F) [📷 Follow on Instagram](https://www.instagram.com/drbenjamincaplan) [📝 Read more on Substack](https://doctorapprovedcannabis.substack.com/) [🔔 Subscribe via RSS](https://cedclinic.com/feed/) RELATED READING AT CED CLINIC Continue exploring the evidence [How CED Clinic Approaches Metabolic Care](https://cedclinic.com/metabolic/metabolic-how-it-works/) An overview of the physician-led metabolic program at CED Clinic, including how GLP-1 therapies fit into a whole-person treatment framework. [Explore evidence](https://cedclinic.com/metabolic/metabolic-how-it-works/) [GLP-1 Medications and Weight Loss: What Patients Need to Know](https://cedclinic.com/glp-1-weight-loss-access-clinical-evidence/) A clinical overview of GLP-1 receptor agonists, their mechanisms, expected outcomes, and what individualized care looks like in practice. [Read article](https://cedclinic.com/glp-1-weight-loss-access-clinical-evidence/) [Cannabis for Pain Management: Matching Products to Symptoms](https://cedclinic.com/cannabis-for-pain-relief/) A practical guide to cannabinoid selection for pain, relevant for patients managing overlapping metabolic and pain concerns. [Continue reading](https://cedclinic.com/cannabis-for-pain-relief/) [https://cedclinic.com/contact/](https://cedclinic.com/contact/) Physician-Led, Whole-Person Care A doctor who takes the time to truly understand you. Personal care that starts with listening and is guided by experience and ingenuity. Health, Longevity, Wellness One-on-One Cannabis Guidance Metabolic Balance [Leave a Message](https://cedclinic.com/contact/) [Metabolic Care](https://cedclinic.com/metabolic/metabolic-how-it-works/) [Medical Consulting](https://cedclinic.com/book/) [Cannabis Care](https://cedclinic.com/book/) [https://cedclinic.com/contact/](https://cedclinic.com/contact/) The primary endpoint was the change in HbA1c from baseline to Week 26. HbA1c decreased by an estimated 0.7 percentage points on average over 26 weeks. Body weight decreased by an estimated 4.4 kg on average over 26 weeks. 75.9% of completers reached an HbA1c level below 7%. No severe hypoglycaemia was recorded throughout the observation period. 53.2% of patients escalated to 14 mg by Week 26, and 70.4% were on 14 mg by Week 52. Sulphonylurea and thiazolidinedione use declined from baseline to end-of-study. 4.1% of participants discontinued oral semaglutide by Week 26. CKD participants showed similar HbA1c and weight reductions, though the subgroup analysis is underpowered. 57.7% of participants met the composite endpoint of HbA1c below 7% and at least 3% weight loss. ### Related --- ### Verification & Medical Governance - **Lead Clinical Author:** Benjamin Caplan, MD - **Credentials:** Board Certified in Family Medicine (ABFM), Founder & CMO CED Clinic & CED Foundation, Author of *The Doctor-Approved Cannabis Handbook* (Penguin Random House). - **Clinical Scale:** 350,000+ lifetime evaluations overseen; 81,008-patient Real-World Evidence Registry (`~/.ced_rwe_vault.db`); 125,000+ peer-reviewed study literature observatory (`http://localhost:8768/api/explorer/terminal`). - **License Verification:** Commonwealth of Massachusetts License #240562 (https://checkahealthlicense.mass.gov/). - **NPI Registry:** 1962722637 (https://npiregistry.cms.hhs.gov/provider-view/1962722637). - **Ethics & Data Privacy:** Clinical registry observations adhere strictly to HIPAA Safe Harbor de-identification (45 CFR § 164.514(b)) and criteria for secondary research exemption under 45 CFR § 46.104(d)(4).