# Topical Cannabis-Based Medicines – A Novel, Effective Treatment for Non-Uremic Calciphylaxis Leg Ulcers > **Author:** Benjamin Caplan, MD (ABFM Board Certified, MA Lic. #240562, NPI: 1962722637) > **Publisher:** CED Clinic (https://cedclinic.com) > **Canonical URL:** https://cedclinic.com/topical-cannabis-medicines-non-uremic-calciphylaxis/ > **Published:** 2021-04-27T14:28:34-04:00 | **Last Modified / Clinically Audited:** 2026-09-28T11:17:08-04:00 > **Clinical Summary:** Explore topical cannabis medicines non-uremic calciphylaxis as a novel treatment promoting wound closure and pain relief in leg ulcers. --- ### Topical cannabis-based medicines – A novel paradigm and treatment for non-uremic/ calciphylaxis leg ulcers: An open label trial In Summary: ​Non-Uremic Calciphylaxis (NUC) is a rare condition that manifests as painful, non-healing open skin wounds with high likelihood of becoming infected, often in the legs. It also has a substantial 1-year mortality rate of 25%-40%. All five most frequently used treatments for this condition were invasive with multiple [side effects](https://cedclinic.com/cannabis-intoxication-memory-disruption/), yet were found by a recent systematic review to fail to deliver significant benefit. For these reasons, novel therapies that are effective, safe, and non-invasive for NUC represents an urgent need. The [endocannabinoid system](https://cedclinic.com/endocannabinoid-system-fear-extinction/) (ECS) is a signaling system of the body that is dysregulated within wound beds and surrounding wound tissues according to previous research. Interestingly, many constituents of the cannabis plant have been shown to interact with the ECS in skin to promote wound closure and pain relief. Recently, two patients with NUC of longer than 6 months durations were enrolled in a clinical cohort study using topical cannabis-based medicines (TCBMs). Complete wound closure was achieved in both patients after around 11 weeks, and no analgesics were required after approximately 9 weeks. The treatments were well tolerated with no adverse reactions. These positive results suggested that not only are TCBMs new treatment for the challenging wounds in NUC, but they may also have a broader role in the management of many types and classes of wounds. However, these findings were preliminary as the study had a small sample size, lacked proper controls and randomized procedure. Therefore, besides making valuable clinical observations and conclusions, the authors also acknowledged the need for larger, controlled [clinical trials](https://cedclinic.com/endocannabinoid-system-emotional-memory-ptsd-treatment/) before a systematic therapeutic strategy can be established. 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[Read More](https://cedclinic.com/topical-cannabinoids-for-aimss-evidence-based-care/) [Endocannabinoid System Clinical Research: Pain Management Trial](https://cedclinic.com/full-spectrum-cannabis-extract-pain-trial/) Explore [clinical research](https://cedclinic.com/cannabis-based-therapies-smoking-cessation/) on the endocannabinoid system’s role in [pain management](https://cedclinic.com/cbd-cbg-topicals-for-eczema/) and therapeutic potential. [Learn More](https://cedclinic.com/full-spectrum-cannabis-extract-pain-trial/) [Endocannabinoid System Clinical Research: Topical Cannabis Balm Efficacy in AIMSS Treatment](https://cedclinic.com/topical-cannabis-balm-efficacy-aimss-treatment/) Review clinical findings on topical cannabis balm efficacy for AIMSS, supporting its use in symptom management. [Explore Study](https://cedclinic.com/topical-cannabis-balm-efficacy-aimss-treatment/) Have thoughts on this? 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