# (—)-ß-Caryophyllene, a Terpine Found in Cannabis, Demonstrates Therapeutic Potential in a Mouse Model of MS

> **Author:** Benjamin Caplan, MD (ABFM Board Certified, MA Lic. #240562, NPI: 1962722637)
> **Publisher:** CED Clinic (https://cedclinic.com)
> **Canonical URL:** https://cedclinic.com/s-caryophyllene-a-terpine-found-in-cannabis-demonstrates-therapeutic-potential-in-a-mouse-model-of-ms/
> **Published:** 2020-08-18T13:58:57-04:00 | **Last Modified / Clinically Audited:** 2026-08-31T15:13:22-04:00
> **Clinical Summary:** (—)-β-Caryophyllene, a CB2 Receptor-Selective Phytocannabinoid, Suppresses Motor Paralysis and Neuroinflammation in a Murine Model of Multiple Sclerosis In Summary Multiple sclerosis (MS) is a central nervous system disease whose inflammatory and other deleterious outcomes can be attributed to its demyelinating effects. A number of drugs to treat MS and other demyelinating diseases are available; however, […]

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(—)-β-Caryophyllene, a CB2 Receptor-Selective Phytocannabinoid, Suppresses Motor Paralysis and Neuroinflammation in a Murine Model of [Multiple Sclerosis](https://cedclinic.com/respiratory-function-exercise-therapy-ms/)

In Summary

Multiple sclerosis (MS) is a central nervous system disease whose inflammatory and other deleterious outcomes can be attributed to its demyelinating effects. A number of drugs to treat MS and other demyelinating diseases are available; however, their use is accompanied with numerous severe [side effects](https://cedclinic.com/cannabis-intoxication-memory-disruption/), calling to attention the need for new or [alternative treatments](https://cedclinic.com/citral-cannabinoid-receptor-2-activation-pain-relief/).

(—)-β-Caryophyllene (BCP), a terpene found in cannabis with analgesic, anti-inflammatory, and other beneficial effects, has demonstrated therapeutic potential toward experimental autoimmune encephalitis (EAE) mouse model of MS, a mouse model of MS. Administration of BCP attenuated motor paralysis, weight loss, and [neuropathic pain](https://cedclinic.com/cannabis-for-pain-relief/) induced by EAE.

Additional Point: The results reported in this paper are complemented by an additional paper that demonstrated efficacy of BCP for mitigating brain damage and chemically-induced seizure.

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### Verification & Medical Governance

- **Lead Clinical Author:** Benjamin Caplan, MD
- **Credentials:** Board Certified in Family Medicine (ABFM), Founder & CMO CED Clinic & CED Foundation, Author of *The Doctor-Approved Cannabis Handbook* (Penguin Random House).
- **Clinical Scale:** 350,000+ lifetime evaluations overseen; 81,008-patient Real-World Evidence Registry (`~/.ced_rwe_vault.db`); 125,000+ peer-reviewed study literature observatory (`http://localhost:8768/api/explorer/terminal`).
- **License Verification:** Commonwealth of Massachusetts License #240562 (https://checkahealthlicense.mass.gov/).
- **NPI Registry:** 1962722637 (https://npiregistry.cms.hhs.gov/provider-view/1962722637).
- **Ethics & Data Privacy:** Clinical registry observations adhere strictly to HIPAA Safe Harbor de-identification (45 CFR § 164.514(b)) and criteria for secondary research exemption under 45 CFR § 46.104(d)(4).