# Trial to Reduce Tobacco and Cannabis Use During Pregnancy > **Author:** Benjamin Caplan, MD (ABFM Board Certified, MA Lic. #240562, NPI: 1962722637) > **Publisher:** CED Clinic (https://cedclinic.com) > **Canonical URL:** https://cedclinic.com/feasibility-trial-tobacco-cannabis-pregnancy/ > **Published:** 2026-03-25T01:05:32-04:00 | **Last Modified / Clinically Audited:** 2026-09-28T10:39:45-04:00 > **Clinical Summary:** Explore the feasibility trial tobacco cannabis pregnancy study focusing on reducing substance use during pregnancy with evidence-based interventions. --- ✦ New CED Clinical Relevance  #80High Clinical Relevance  Strong evidence or policy relevance with direct clinical implications. ⚒ Cannabis News  |  CED Clinic Pregnancy[Harm Reduction](https://cedclinic.com/can-you-mix-weed-and-alcohol/)Tobacco Cessation[Clinical Trials](https://cedclinic.com/endocannabinoid-system-emotional-memory-ptsd-treatment/)[Maternal Health](https://cedclinic.com/recreational-cannabis-birth-outcomes-study-colorado/) Why This Matters Pregnancy represents a critical window where substance use interventions can protect both maternal and fetal health outcomes. [Cannabis use](https://cedclinic.com/cannabis-cardiovascular-health-insights-2024/) during pregnancy has increased significantly, yet evidence-based treatment protocols remain limited, making feasibility studies essential for developing safe, effective interventions. Clinical Summary This feasibility trial examines interventions to reduce both tobacco and [cannabis use](https://cedclinic.com/cannabis-cardiovascular-health-insights-2024/) during pregnancy, addressing a gap in evidence-based treatment approaches for pregnant patients. The study focuses on acceptability and preliminary efficacy of combined cessation strategies. Cannabis use during pregnancy has been associated with potential risks including low birth weight and neurodevelopmental concerns, though mechanisms remain incompletely understood. The dual-substance approach recognizes that many pregnant patients use both tobacco and cannabis concurrently. Dr. Caplan’s Take “We desperately need evidence-based approaches for pregnant patients using cannabis — the ‘just say no’ approach isn’t working, and we’re seeing more patients who need practical, safe reduction strategies that acknowledge the complexity of substance use during pregnancy.” Clinical Perspective 🧠 Clinicians should monitor this research for potential evidence-based protocols that move beyond abstinence-only messaging. For current practice, focus on non-judgmental screening, [harm reduction](https://cedclinic.com/can-you-mix-weed-and-alcohol/) counseling, and individualized risk-benefit discussions. Consider that patients may be more receptive to gradual reduction approaches than immediate cessation demands. 💬 Join the Conversation Have a question about how this applies to your situation? [Ask Dr. Caplan →](https://benjamincaplan.com/ask-dr-caplan) Want to discuss this topic with other patients and caregivers? [Join the forum discussion →](https://cedclinic.com/interact/discussion-forums/) Have thoughts on this? Share it: [𝕏 Share on X](https://twitter.com/intent/tweet?text=Just%20read%20this%20on%20CEDclinic.com%3A%20Feasibility%20and%20Acceptability%20Trial%20to%20Reduce%20Tobacco%20and%20Cannabis%20Use%20During%20Pr...%20%40drcaplan&url=https%3A//clinicaltrials.gov/study/NCT07489443)[in Share on LinkedIn](https://www.linkedin.com/sharing/share-offsite/?url=https%3A//clinicaltrials.gov/study/NCT07489443)[🦥 Share on BlueSky](https://bsky.app/intent/compose?text=Just%20read%20this%3A%20Feasibility%20and%20Acceptability%20Trial%20to%20Reduce%20Tobacco%20and%20Cannabis%20Use%20During%20Pr...%20--%20via%20%40drcaplan.bsky.social%20https%3A//clinicaltrials.gov/study/NCT07489443)[📷 Follow on Instagram](https://www.instagram.com/drbenjamincaplan/)[📝 Read more on Substack](https://substack.com/@doctorapproved)[🔔 Subscribe via RSS](https://cedclinic.com/category/cannabis-news/feed/) 📰 Source: [https://clinicaltrials.gov/study/NCT07489443](https://clinicaltrials.gov/study/NCT07489443) Table of Contents - [FAQ](#FAQ)[What is the clinical relevance rating of this cannabis research?](#What_is_the_clinical_relevance_rating_of_this_cannabis_research) - [What topics does this cannabis study cover?](#What_topics_does_this_cannabis_study_cover) - [Why is cannabis research during pregnancy considered clinically significant?](#Why_is_cannabis_research_during_pregnancy_considered_clinically_significant) - [How does this research relate to tobacco cessation efforts?](#How_does_this_research_relate_to_tobacco_cessation_efforts) - [What makes this cannabis research relevant for clinical practice?](#What_makes_this_cannabis_research_relevant_for_clinical_practice) - [Related](#Related) ## FAQ #### What is the clinical relevance rating of this cannabis research? This research has been assigned a “High Clinical Relevance” rating (#80) by CED Clinical. This indicates strong evidence or policy relevance with direct clinical implications for healthcare providers. #### What topics does this cannabis study cover? The study focuses on multiple important areas including pregnancy, harm reduction, tobacco cessation, and [clinical trials](https://cedclinic.com/endocannabinoid-system-emotional-memory-ptsd-treatment/). These interconnected topics suggest research examining cannabis use patterns and health interventions in vulnerable populations. #### Why is cannabis research during pregnancy considered clinically significant? Cannabis use during pregnancy has direct implications for maternal and fetal health outcomes. Healthcare providers need evidence-based guidance to counsel pregnant patients about potential risks and benefits of cannabis use. #### How does this research relate to tobacco cessation efforts? The study likely examines cannabis as a potential harm reduction tool for tobacco cessation, particularly in pregnant women. This represents an important clinical consideration given the known severe risks of tobacco use during pregnancy. #### What makes this cannabis research relevant for clinical practice? The high clinical relevance rating indicates this research provides actionable evidence for healthcare providers. It likely offers practical guidance for [patient counseling](https://cedclinic.com/stroke-risk-assessment-substance-use/), treatment decisions, or policy implementation in clinical settings. {“@context”: “https://schema.org”, “@type”: “NewsArticle”, “headline”: “Feasibility and Acceptability Trial to Reduce Tobacco and Cannabis Use During Pregnancy …”, “url”: “https://clinicaltrials.gov/study/NCT07489443”, “datePublished”: “2026-03-24T20:48:24Z”, “about”: “feasibility acceptability trial reduce tobacco cannabis”} [https://cedclinic.com/contact/](https://cedclinic.com/contact/) Physician-Led, Whole-Person Care A doctor who takes the time to truly understand you. Personal care that starts with listening and is guided by experience and ingenuity. Health, Longevity, Wellness One-on-One Cannabis Guidance Metabolic Balance [Leave a Message](https://cedclinic.com/contact/) [Metabolic Care](https://cedclinic.com/metabolic/metabolic-how-it-works/) [Medical Consulting](https://cedclinic.com/book/) [Cannabis Care](https://cedclinic.com/book/) [https://cedclinic.com/contact/](https://cedclinic.com/contact/) RELATED READING AT CED CLINIC Continue exploring the evidence [New Clinical Insights on Cannabis and Patient Outcomes](https://cedclinic.com/new-clinical-insights-on-cannabis-and-patient-outcomes/) Discover recent clinical findings on cannabis use and its impact on patient health outcomes, relevant for understanding pregnancy-related research. [Read More](https://cedclinic.com/new-clinical-insights-on-cannabis-and-patient-outcomes/) [Cannabinoid Clinical Trials: Mental Health & Addiction Review](https://cedclinic.com/cannabinoid-clinical-trials-mental-health-substance-use-treatment/) Review clinical trials focusing on cannabinoids, mental health, and addiction, providing context for substance use interventions during pregnancy. [Explore Study](https://cedclinic.com/cannabinoid-clinical-trials-mental-health-substance-use-treatment/) [Rescheduling Marijuana and Research Opportunities](https://cedclinic.com/rescheduling-marijuana-research-barriers-thc-cbd-studies/) Learn how marijuana rescheduling could enhance research opportunities on THC and CBD, impacting future pregnancy-related substance use studies. [Learn More](https://cedclinic.com/rescheduling-marijuana-research-barriers-thc-cbd-studies/) ### Related --- ### Verification & Medical Governance - **Lead Clinical Author:** Benjamin Caplan, MD - **Credentials:** Board Certified in Family Medicine (ABFM), Former CMO Canna Care Docs (250,000+ patients supervised), Founder & CMO CED Clinic & CED Foundation, Author of *The Doctor-Approved Cannabis Handbook* (Penguin Random House). - **Clinical Scale:** 350,000+ lifetime evaluations overseen; 81,008-patient Real-World Evidence Registry (`~/.ced_rwe_vault.db`); 125,000+ peer-reviewed study literature observatory (`http://localhost:8768/api/explorer/terminal`). - **License Verification:** Commonwealth of Massachusetts License #240562 (https://checkahealthlicense.mass.gov/). - **NPI Registry:** 1962722637 (https://npiregistry.cms.hhs.gov/provider-view/1962722637). - **Ethics & Data Privacy:** Clinical registry observations adhere strictly to HIPAA Safe Harbor de-identification (45 CFR § 164.514(b)) and criteria for secondary research exemption under 45 CFR § 46.104(d)(4).