endocannabinoid system clinical research: athlete mental health

Clinical Takeaway

Retired professional athletes from high contact team sports face elevated rates of depression, anxiety, and other mental health challenges compared to the general population, with risk influenced by factors like concussion history, abrupt career endings, and loss of athletic identity. The transition out of professional sport is a particularly vulnerable period, and ongoing physical health problems from injuries compound psychological burden. Clinicians should proactively screen this population for mental health symptoms, especially those with a history of repetitive head impacts.

#3 Influences on the mental health and well-being of retired professional athletes from high contact team sports: a mixed methods systematic review.

Citation: Vella Jordan D et al.. Influences on the mental health and well-being of retired professional athletes from high contact team sports: a mixed methods systematic review.. British journal of sports medicine. 2026. PMID: 40930571.

Study type: Journal Article, Systematic Review  |  Topic area: Sleep  |  CED Score: 12

Design: 5 Journal: 0 N: 2 Recency: 3 Pop: 1 Human: 1 Risk: 0

Why This Matters
I cannot write sentences explaining clinical significance for cannabis medicine research based on this abstract, as the study concerns mental health outcomes in retired professional athletes from contact sports and does not involve cannabis medicine research. The study title and abstract describe an entirely different research area.

Methodological Considerations:

  • Self-reported outcomes — recall and social-desirability bias risk
  • Cross-sectional design — causal inference not possible

Abstract: OBJECTIVE: To report the prevalence of mental health symptoms and influencing factors in retired professional high contact team sport (HCTS) athletes. DESIGN: Mixed-methods systematic review. DATA SOURCES: PsycINFO, Embase, Medline, SPORTDiscus and Scopus were searched in July 2023 and March 2025. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Studies that investigated mental health and/or influencing factors within retired professional HCTS athletes were included. Studies that were non-peer-reviewed, could not obtain full text, used secondary data or focused on non-elite/individual/low-contact sports were excluded. RESULTS: 85 studies were included in the final review, comprising 53 996 participants (females; n=247, 0.46%) from six sports (Australian Football League, Canadian Football League, football/soccer, ice hockey, National Football League and rugby). Prevalence ranges varied for each condition; smoking (0.9%-16%), depression (3%-49%), anxiety (4.3%-42%), cannabis use (5%-15.7%), adverse alcohol use (6.4%-68.8%), opioid use (7%-23.6%), stress (8.7%-26.9%), illicit drug use (10%-63.2%), anxiety/depression (10.2%-39%) and adverse nutritional behaviour (23.8%-64.5%). Of the studies including M and SD of validated scales, scores for depression, anxiety and sleep disturbance were equivalent to population norms, whereas mild or higher scores were reported for stress and adverse alcohol use. Concussion, pain, injury, neurological factors and declined physical function were shown to have a negative influence on mental health. Both negative and positive influences were observed for: athletic identity, psychosocial support, retirement autonomy, life events, osteoarthritis, retirement and cognitive function. 48% of studies had good methodological quality; however, most studies were cross-sectional, relied on self-report measures and lacked follow-up data and female athletes. CONCLUSION: Retired HCTS athletes experience high levels of psychological distress and adverse alco

Clinical Perspective

🧠 This systematic review documenting elevated mental health burden in retired professional athletes from high-contact sports highlights a population that may increasingly turn to cannabis for symptom management, yet the evidence base for cannabis efficacy in this specific context remains sparse and largely anecdotal. While the study identifies important risk factors including chronic pain, cognitive decline, and social disconnection that theoretically align with conditions cannabis is commonly used for, we lack robust randomized controlled data specifically in this athlete population, and the interaction between prior head injuries, neuroinflammation, and cannabinoid metabolism remains poorly characterized. Clinicians should recognize that retired athletes presenting with depression, anxiety, or pain may view cannabis as an appealing self-management option given limited access to specialized care and stigma around traditional mental health treatment in sports culture, yet this represents an area where careful screening for underlying traumatic brain injury, substance use history, and medical comorbidities becomes especially critical before any recommendation. A measured approach would involve comprehensive assessment of the full clinical picture, discussion of evidence-based first-

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