# Cannabidiol Effects on Autism Anxiety and Parental Stress > **Author:** Benjamin Caplan, MD (ABFM Board Certified, MA Lic. #240562, NPI: 1962722637) > **Publisher:** CED Clinic (https://cedclinic.com) > **Canonical URL:** https://cedclinic.com/effects-cannabidiol-autism-anxiety-parental-stress/ > **Published:** 2026-04-25T14:21:17-04:00 | **Last Modified / Clinically Audited:** 2026-09-28T10:57:41-04:00 > **Clinical Summary:** Explore effects cannabidiol autism anxiety parental stress in autistic children with CBD oil at 10 mg/kg/day in a randomized controlled trial. --- #### Clinical Takeaway CBD oil at 10 mg/kg/day showed improvements in social relating, anxiety symptoms, and parental stress levels in autistic children aged 5-12 years compared to placebo in this randomized controlled trial. The double-blind, crossover design strengthens confidence in these findings as the primary outcome measures directly address common challenges in [autism spectrum disorder](https://cedclinic.com/pediatric-cannabis-use-autism-adhd-tourette-safety/). Additional research with larger sample sizes is needed to establish optimal dosing, [long-term safety](https://cedclinic.com/cannabis-tobacco-brain-volume-study/), and which autistic subpopulations may benefit most from CBD treatment. ### #27 Effects of Cannabidiol on Social Relating, Anxiety, and Parental Stress in Autistic Children: A Randomized Controlled Crossover Trial. **Citation:** Parrella Nina-Francesca et al. *Effects of Cannabidiol on Social Relating, Anxiety, and Parental Stress in Autistic Children: A Randomized Controlled Crossover Trial.* Autism research: official journal of the International Society for Autism Research. 2026. PMID: 41452412. **Study type:** Journal Article, Randomized Controlled Trial  |  **Topic area:** Autism  |  **CED Score:** 10 Design: 5 Journal: 0 N: 0 Recency: 3 Pop: 3 Human: 1 Risk: -2 **Quality Gate Alerts:** - Preclinical only **Abstract:** Cannabidiol (CBD), a non-intoxicating compound derived from the cannabis plant, has garnered increasing attention as a potential pharmacological therapeutic for autism. We conducted a randomized, double-blind, placebo-controlled, crossover trial to understand whether oral CBD oil containing terpenes can improve outcomes in autistic children. Twenty-nine children (18 male), aged 5 to 12 years (M = 9.62 years, SD = 2.05), diagnosed with [autism spectrum](https://cedclinic.com/cbd-neuropsychiatric-symptoms-tuberous-sclerosis-epicom-trial/) disorder, completed the study. Participants received weight-based dosing of CBD oil (10 mg/kg/day) or matched placebo oil over two 12-week intervention periods (crossover), separated by an 8-week washout period. Outcome measures included the Social Responsiveness Scale-2 (SRS-2; primary outcome), PROMIS Social Relating, Anxiety, and Sleep, Developmental Behavior Checklist-2 (DBC-2), Vineland-3, and Autism Parenting Stress Index (APSI; secondary outcomes). There was no significant effect observed for the primary outcome measure (SRS-2) for CBD oil relative to placebo oil after 12 weeks (β = -11.15, SE = 7.19, p = 0.125). Significant improvements were observed in secondary measures of social functioning, including DBC-2 Social Relating (β = -2.35, SE = 0.92, p(adj) = 0.024), as well as reduced anxiety on the DBC-2 subscale (β = -3.20, SE = 0.94, p(adj) = 0.002), and lower parental stress (APSI; β = -4.63, SE = 2.26, p(adj) = 0.044). No differences were detected on Vineland-3 adaptive functioning (ABC: β = 2.06, SE = 2.67, p(adj) = 1.000), and domain scores were not significant. Safety and tolerability data indicated that two children experienced gastrointestinal discomfort while taking CBD. Findings from this pilot trial suggest that while CBD combined with terpenes did not improve the primary outcome of social responsiveness, it may hold potential in addressing certain autism-related difficulties, particularly anxiety and social relating. Further research with larger sample sizes is needed to fully evaluate the efficacy  |  [View on PubMed ↗](https://pubmed.ncbi.nlm.nih.gov/41452412/)[DOI ↗](https://doi.org/10.1002/aur.70159) [https://cedclinic.com/contact/](https://cedclinic.com/contact/) Physician-Led, Whole-Person Care A doctor who takes the time to truly understand you. Personal care that starts with listening and is guided by experience and ingenuity. 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[Read More](https://cedclinic.com/cannabinoid-clinical-benefits-autism-cbd-trial/) [Effects of Cannabidiol on Social Relating, Anxiety, and Parental Stress in Autistic Children](https://cedclinic.com/cbd-autism-social-communication-effects-anxiety-stress/) Detailed findings on how cannabidiol affects social relating, anxiety, and parental stress in autistic children. [Explore Study](https://cedclinic.com/cbd-autism-social-communication-effects-anxiety-stress/) [Clinical Trial of CBD Oil Effects on Autism and Anxiety](https://cedclinic.com/cbd-oil-autism-anxiety-trial/) Insights from a clinical trial assessing CBD oil's impact on autism and anxiety symptoms. [Learn More](https://cedclinic.com/cbd-oil-autism-anxiety-trial/) Have thoughts on this? 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