# Daily Research & Patient Questions > **Author:** Benjamin Caplan, MD (ABFM Board Certified, MA Lic. #240562, NPI: 1962722637) > **Publisher:** CED Clinic (https://cedclinic.com) > **Canonical URL:** https://cedclinic.com/daily-literature-hub/ > **Published:** 2026-09-16T22:43:59-04:00 | **Last Modified / Clinically Audited:** 2026-09-17T13:37:45-04:00 > **Clinical Summary:** Curated daily peer-reviewed cannabinoid research, PubMed summaries, clinical trial data, and evidence analysis reviewed by Dr. Benjamin Caplan. --- CED Clinic Research Theater Table of Contents - [Daily Research & Patient Literature Board](#Daily_Research_Patient_Literature_Board)[Literature Presentation Boards](#Literature_Presentation_Boards) - [Cannabis Use Disorder and Postoperative Pain: Elevated Analgesic Requirements After Surgical Repair of Hand Fractures](#Cannabis_Use_Disorder_and_Postoperative_Pain_Elevated_Analgesic_Requirements_After_Surgical_Repair_of_Hand_Fractures) - [Cannabis stigma and symptom management considerations in cancer survivors: a mixed-methods exploration of patient perspectives](#Cannabis_stigma_and_symptom_management_considerations_in_cancer_survivors_a_mixed-methods_exploration_of_patient_perspectives) - [Does Cannabinoid Use Reduce Opioid Utilization Among Patients with Gastrointestinal Cancer? Evidence from Epic COSMOS](#Does_Cannabinoid_Use_Reduce_Opioid_Utilization_Among_Patients_with_Gastrointestinal_Cancer_Evidence_from_Epic_COSMOS) - [Lower Pain Intensity Is Associated with the Use of Recreational Edible Cannabis Products Containing Delta-9-Tetrahydrocannabinol: A Secondary Analysis in Adults Self-Managing Their Chronic Low Back Pain](#Lower_Pain_Intensity_Is_Associated_with_the_Use_of_Recreational_Edible_Cannabis_Products_Containing_Delta-9-Tetrahydrocannabinol_A_Secondary_Analysis_in_Adults_Self-Managing_Their_Chronic_Low_Back_Pain) - [Long-Term Efficacy and Safety of Inhaled Cannabis Therapy for Painful Diabetic Neuropathy: A 5-Year Longitudinal Observational Study](#Long-Term_Efficacy_and_Safety_of_Inhaled_Cannabis_Therapy_for_Painful_Diabetic_Neuropathy_A_5-Year_Longitudinal_Observational_Study) - [Major depressive disorder in children and adolescents is associated with reduced hair cortisol and anandamide (AEA): cross-sectional and longitudinal evidence from a large randomized clinical trial](#Major_depressive_disorder_in_children_and_adolescents_is_associated_with_reduced_hair_cortisol_and_anandamide_AEA_cross-sectional_and_longitudinal_evidence_from_a_large_randomized_clinical_trial) - [Cannabis, Pain, and Complications: A Prospective Analysis of Cannabis Use, Opiate Consumption, and Postoperative Outcomes following Cancer-Related Abdominal Surgery](#Cannabis_Pain_and_Complications_A_Prospective_Analysis_of_Cannabis_Use_Opiate_Consumption_and_Postoperative_Outcomes_following_Cancer-Related_Abdominal_Surgery) - [Changes in Cross-Sectional Associations Between Cannabis Use and Anxiety, Depression, and Suicidality in a Nationally Representative Sample of Canadians From 2012 to 2022: Évolution des relations transversales entre la consommation de cannabis et la dépression, l’anxiété et les idées suicidaires au sein d’un échantillon représentatif de Canadiens à l’échelle nationale, de 2012 à 2022](#Changes_in_Cross-Sectional_Associations_Between_Cannabis_Use_and_Anxiety_Depression_and_Suicidality_in_a_Nationally_Representative_Sample_of_Canadians_From_2012_to_2022_Evolution_des_relations_transversales_entre_la_consommation_de_cannabis_et_la_depression_lanxiete_et_les_idees_suicidaires_au_sein_dun_echantillon_representatif_de_Canadiens_a_lechelle_nationale_de_2012_a_2022) - [Blowing Minds: A cross-cultural, longitudinal investigation to unravel the highs and lows of recreational and medicinal cannabis users](#Blowing_Minds_A_cross-cultural_longitudinal_investigation_to_unravel_the_highs_and_lows_of_recreational_and_medicinal_cannabis_users) - [Cannabis and tobacco co-use predicts psychosis in clinical high risk cohorts](#Cannabis_and_tobacco_co-use_predicts_psychosis_in_clinical_high_risk_cohorts) - [Ask Dr. Caplan a Question & Explore Answered Patient Archive](#Ask_Dr_Caplan_a_Question_Explore_Answered_Patient_Archive) - [Have a Question?](#Have_a_Question) - [Daily Answered Q&A Corkboard Stream](#Daily_Answered_QA_Corkboard_Stream)[“Does ingesting cannabis nano emulsions effect nitric oxide production”](#ldquoDoes_ingesting_cannabis_nano_emulsions_effect_nitric_oxide_productionrdquo) - [“I have PTSD and keep hearing that cannabis is a lifesaver for trauma. Does medical cannabis actually treat PTSD, or does the clinical research show it can make symptoms worse?”](#ldquoI_have_PTSD_and_keep_hearing_that_cannabis_is_a_lifesaver_for_trauma_Does_medical_cannabis_actually_treat_PTSD_or_does_the_clinical_research_show_it_can_make_symptoms_worserdquo) - [“Why does a low dose of cannabis help my anxiety and pain, but if I take slightly more it suddenly makes my anxiety worse and my heart race? Why does it flip like that?”](#ldquoWhy_does_a_low_dose_of_cannabis_help_my_anxiety_and_pain_but_if_I_take_slightly_more_it_suddenly_makes_my_anxiety_worse_and_my_heart_race_Why_does_it_flip_like_thatrdquo) - [“Is THCV truly an appetite suppressant? Why isn't it all over the market?”](#ldquoIs_THCV_truly_an_appetite_suppressant__Why_isn039t_it_all_over_the_marketrdquo) - [“I have a root canal coming up and someone suggested taking CBD beforehand to calm my nerves and help with the pain after. Does that work?”](#ldquoI_have_a_root_canal_coming_up_and_someone_suggested_taking_CBD_beforehand_to_calm_my_nerves_and_help_with_the_pain_after_Does_that_workrdquo) - [“I am starting chemotherapy next month and I am already nauseous just thinking about it. Does cannabis actually help with that, or is it wishful thinking?”](#ldquoI_am_starting_chemotherapy_next_month_and_I_am_already_nauseous_just_thinking_about_it_Does_cannabis_actually_help_with_that_or_is_it_wishful_thinkingrdquo) - [“Does medical cannabis help with cancer pain and the general awfulness of advanced cancer?”](#ldquoDoes_medical_cannabis_help_with_cancer_pain_and_the_general_awfulness_of_advanced_cancerrdquo) - [“Is there any evidence for cannabis helping tics in Tourette syndrome? My son has tried a lot of medications without much luck.”](#ldquoIs_there_any_evidence_for_cannabis_helping_tics_in_Tourette_syndrome_My_son_has_tried_a_lot_of_medications_without_much_luckrdquo) - [“My father has Parkinson's and keeps reading that cannabis helps with tremor. Is there anything behind that?”](#ldquoMy_father_has_Parkinson039s_and_keeps_reading_that_cannabis_helps_with_tremor_Is_there_anything_behind_thatrdquo) - [How we cite research](#How_we_cite_research) - [Thank you for your question](#Thank_you_for_your_question) ## Daily Research & Patient Literature Board New research, explained two ways: a plain-English summary and a deeper scientific read. 📋 ### Literature Presentation Boards Browse recent studies from the clinical literature. [✓ PMID: 42077538 ↗](https://pubmed.ncbi.nlm.nih.gov/42077538) Plastic and Reconstructive Surgery - Global Open • 2026 ### Cannabis Use Disorder and Postoperative Pain: Elevated Analgesic Requirements After Surgical Repair of Hand Fractures 🔬 Study Overview: Researchers studied medical records to compare pain medication use after hand fracture surgery between patients diagnosed with problematic cannabis habits and those without such a diagnosis. [Read the findings and why they matter →](https://cedclinic.com/research/cannabis-for-cannabis-use-3/) Reviewed by Dr. Caplan [✓ PMID: 41820694 ↗](https://pubmed.ncbi.nlm.nih.gov/41820694) Human study Supportive Care in Cancer • 2026 ### Cannabis stigma and symptom management considerations in cancer survivors: a mixed-methods exploration of patient perspectives 🔬 Study Overview: Researchers investigated what cancer survivors think about using cannabis and whether they worry about being judged for it. [Read the findings and why they matter →](https://cedclinic.com/research/medical-marijuana-for-cancer-observational-study/) Reviewed by Dr. Caplan [✓ PMID: 41976333 ↗](https://pubmed.ncbi.nlm.nih.gov/41976333) Cancers • 2026 ### Does Cannabinoid Use Reduce Opioid Utilization Among Patients with Gastrointestinal Cancer? Evidence from Epic COSMOS 🔬 Study Overview: Researchers studied whether patients with digestive system cancers who received prescriptions for Food and Drug Administration-approved cannabis medications during early chemotherapy reduced their reliance on opioid pain medications. [Read the findings and why they matter →](https://cedclinic.com/research/cannabinoids-for-cancer/) Reviewed by Dr. Caplan [✓ PMID: 42512114 ↗](https://pubmed.ncbi.nlm.nih.gov/42512114) Biomedicines • 2026 ### Lower Pain Intensity Is Associated with the Use of Recreational Edible Cannabis Products Containing Delta-9-Tetrahydrocannabinol: A Secondary Analysis in Adults Self-Managing Their Chronic Low Back Pain 🔬 Study Overview: Researchers followed adults living with long-term lower back pain who chose to use edible cannabis products from legal stores over a two-week period. [Read the findings and why they matter →](https://cedclinic.com/research/cannabis-for-pain/) Reviewed by Dr. Caplan [✓ PMID: 41153689 ↗](https://pubmed.ncbi.nlm.nih.gov/41153689) Biomedicines • 2025 ### Long-Term Efficacy and Safety of Inhaled Cannabis Therapy for Painful Diabetic Neuropathy: A 5-Year Longitudinal Observational Study 🔬 Study Overview: This study followed 52 people with long-lasting nerve pain caused by diabetes who had not improved with standard medicines. [Read the findings and why they matter →](https://cedclinic.com/research/cannabis-for-pain-observational-study/) Reviewed by Dr. Caplan [✓ PMID: 40413177 ↗](https://pubmed.ncbi.nlm.nih.gov/40413177) Randomized controlled trial Translational Psychiatry • 2025 ### Major depressive disorder in children and adolescents is associated with reduced hair cortisol and anandamide (AEA): cross-sectional and longitudinal evidence from a large randomized clinical trial 🔬 Study Overview: This study looked at young people aged 8 to 17 who had depression, and compared them with young people without depression. [Read the findings and why they matter →](https://cedclinic.com/research/hydrocortisone-for-major-depressive-disorder-randomized-controlled-trial/) Reviewed by Dr. Caplan [✓ PMID: 41131391 ↗](https://pubmed.ncbi.nlm.nih.gov/41131391) Human study Annals of Surgical Oncology • 2026 ### Cannabis, Pain, and Complications: A Prospective Analysis of Cannabis Use, Opiate Consumption, and Postoperative Outcomes following Cancer-Related Abdominal Surgery 🔬 Study Overview: Researchers followed adults undergoing major abdominal operations for cancer to see how regular use of cannabis affects pain levels, pain medication needs, and recovery complications. [Read the findings and why they matter →](https://cedclinic.com/research/opioid-analgesics-for-postoperative-pain-observational-study/) Reviewed by Dr. Caplan [✓ PMID: 41746129 ↗](https://pubmed.ncbi.nlm.nih.gov/41746129) Human study The Canadian Journal of Psychiatry • 2026 ### Changes in Cross-Sectional Associations Between Cannabis Use and Anxiety, Depression, and Suicidality in a Nationally Representative Sample of Canadians From 2012 to 2022: Évolution des relations transversales entre la consommation de cannabis et la dépression, l’anxiété et les idées suicidaires au sein d’un échantillon représentatif de Canadiens à l’échelle nationale, de 2012 à 2022 🔬 Study Overview: Researchers analyzed two large national health surveys from Canada conducted ten years apart to understand how cannabis use relates to anxiety, depression, and thoughts of suicide over time. [Read the findings and why they matter →](https://cedclinic.com/research/marijuana-use-for-major-depressive-disorder/) Reviewed by Dr. Caplan [✓ PMID: 41496191 ↗](https://pubmed.ncbi.nlm.nih.gov/41496191) Human study Comprehensive Psychiatry • 2026 ### Blowing Minds: A cross-cultural, longitudinal investigation to unravel the highs and lows of recreational and medicinal cannabis users 🔬 Study Overview: The Blowing Minds protocol establishes a robust framework to evaluate the complex, real-world interactions between cannabis use (medicinal vs. recreational), affect, cognition, and legal context using ecological momentary assessment. [Read the findings and why they matter →](https://cedclinic.com/research/medicinal-cannabis-for-marijuana-abuse/) Reviewed by Dr. Caplan [✓ PMID: 42291778 ↗](https://pubmed.ncbi.nlm.nih.gov/42291778) Nature Mental Health • 2026 ### Cannabis and tobacco co-use predicts psychosis in clinical high risk cohorts 🔬 Study Overview: The study looked at individuals at high risk for psychosis and healthy controls to understand the effects of cannabis and tobacco use. [Read the findings and why they matter →](https://cedclinic.com/research/cannabis-for-psychosis/) Reviewed by Dr. Caplan 📌 PHYSICIAN-LED CLINICAL DIALOGUE ### Ask Dr. Caplan a Question & Explore Answered Patient Archive Submit an anonymous question for physician review or browse verified scientific answers on our daily corkboard. Ask / View Answers ✍️ Ask: | Click to Open Audience Q&A Submission Notepad ### Have a Question? Submit your question below. Selected questions are answered after physician review. Write Your Question Here: This board is for general education. Please don't include your name, date of birth, or personal health details. Answers are not medical advice and don't create a doctor-patient relationship. For care specific to you, [book a consultation](https://cedclinic.com/book/). In an emergency, call 911. Pin Anonymously Your name or handle 📌 ### Daily Answered Q&A Corkboard Stream Patient questions, answered by a physician. Asked by Anonymous reader Oct 4, 2026 #### “Does ingesting cannabis nano emulsions effect nitric oxide production” BC Dr. Caplan & CED Research Response Answered We do not currently have human studies showing that cannabis nanoemulsions directly increase or decrease nitric oxide production. [Read the full answer →](https://cedclinic.com/questions/does-ingesting-cannabis-nano-emulsions-effect-nitric-oxide-production/) [✓ Ref: PMID 26092099 ↗](https://pubmed.ncbi.nlm.nih.gov/26092099/) Asked by Anonymous reader Sep 22, 2026 #### “I have PTSD and keep hearing that cannabis is a lifesaver for trauma. Does medical cannabis actually treat PTSD, or does the clinical research show it can make symptoms worse?” BC Dr. Caplan & CED Research Response Answered Clinical research indicates that cannabinoids do not "cure" PTSD or reliably lower total PTSD severity scores across the board, but they can offer targeted temporary relief for specific symptom clusters like traumatic nightmares, sleep disruption, and intense hyperarousal. [Read the full answer →](https://cedclinic.com/questions/does-medical-cannabis-effectively-treat-ptsd-or-does-research-show-risks/) [✓ Ref: PMID 38353645 ↗](https://pubmed.ncbi.nlm.nih.gov/38353645) Systematic review or meta-analysis Asked by Anonymous reader Sep 22, 2026 #### “Why does a low dose of cannabis help my anxiety and pain, but if I take slightly more it suddenly makes my anxiety worse and my heart race? Why does it flip like that?” BC Dr. Caplan & CED Research Response Answered Cannabis compounds often produce what pharmacologists call a "biphasic effect," meaning low doses and higher doses can produce opposite reactions in the body. [Read the full answer →](https://cedclinic.com/questions/cannabis-for-anxiety-question/) [✓ Ref: PMID 38268491 ↗](https://pubmed.ncbi.nlm.nih.gov/38268491) Systematic review or meta-analysis Asked by Anonymous reader Sep 19, 2026 #### “Is THCV truly an appetite suppressant? Why isn't it all over the market?” BC Dr. Caplan & CED Research Response Answered While early research suggests tetrahydrocannabivarin (THCV) may reduce appetite in some contexts, the evidence is not yet strong enough to call it a reliable or proven weight-loss tool. [Read the full answer →](https://cedclinic.com/questions/is-thcv-truly-an-appetite-suppressant-why-isnt-it-all/) [✓ Ref: PMID 38995871 ↗](https://pubmed.ncbi.nlm.nih.gov/38995871/) Narrative review Asked by Anonymous reader Sep 17, 2026 #### “I have a root canal coming up and someone suggested taking CBD beforehand to calm my nerves and help with the pain after. Does that work?” BC Dr. Caplan & CED Research Response Answered The one trial that tested exactly this did not find a benefit. [Read the full answer →](https://cedclinic.com/questions/cbd-for-postoperative-pain-question/) [✓ Ref: PMID 39505200 ↗](https://pubmed.ncbi.nlm.nih.gov/39505200) Randomized controlled trial Asked by Anonymous reader Sep 17, 2026 #### “I am starting chemotherapy next month and I am already nauseous just thinking about it. Does cannabis actually help with that, or is it wishful thinking?” BC Dr. Caplan & CED Research Response Answered For nausea that persists despite standard anti-sickness medicine, there is real evidence it helps. [Read the full answer →](https://cedclinic.com/questions/cannabis-for-nausea-question/) [✓ Ref: PMID 39151115 ↗](https://pubmed.ncbi.nlm.nih.gov/39151115) Randomized controlled trial Asked by Anonymous reader Sep 17, 2026 #### “Does medical cannabis help with cancer pain and the general awfulness of advanced cancer?” BC Dr. Caplan & CED Research Response Answered This is a very tricky question - with answers that keep changing with different papers and patient reports. [Read the full answer →](https://cedclinic.com/questions/medical-cannabis-for-cancer-question/) [✓ Ref: PMID 40705150 ↗](https://pubmed.ncbi.nlm.nih.gov/40705150) Randomized controlled trial Asked by Anonymous reader Sep 17, 2026 #### “Is there any evidence for cannabis helping tics in Tourette syndrome? My son has tried a lot of medications without much luck.” BC Dr. Caplan & CED Research Response Answered There is, from a small but carefully designed trial. [Read the full answer →](https://cedclinic.com/questions/thc-for-tourette-syndrome-question/) [✓ Ref: PMID 38320199 ↗](https://pubmed.ncbi.nlm.nih.gov/38320199) Randomized controlled trial Asked by Anonymous reader Sep 17, 2026 #### “My father has Parkinson's and keeps reading that cannabis helps with tremor. Is there anything behind that?” BC Dr. Caplan & CED Research Response Answered For now, less than the enthusiasm suggests. [Read the full answer →](https://cedclinic.com/questions/cannabis-for-parkinsons-tremor-question/) [✓ Ref: PMID 38487964 ↗](https://pubmed.ncbi.nlm.nih.gov/38487964) Randomized controlled trial ### How we cite research Every study linked on this page is checked against PubMed so the link goes to the paper it names. If a study can no longer be verified, any answer relying on it is taken down until a physician reviews it again. Software can confirm that a citation is real. It cannot confirm that a study supports what we wrote. That judgment belongs to our reviewing physicians. Deep Scientific Analysis ### [#](#) ### Thank you for your question Your question has been securely submitted to Dr. Caplan and the CED research team. Selected questions are answered after physician review. --- ### Verification & Medical Governance - **Lead Clinical Author:** Benjamin Caplan, MD - **Credentials:** Board Certified in Family Medicine (ABFM), Founder & CMO CED Clinic & CED Foundation, Author of *The Doctor-Approved Cannabis Handbook* (Penguin Random House). - **Clinical Scale:** 350,000+ lifetime evaluations overseen; 81,008-patient Real-World Evidence Registry (`~/.ced_rwe_vault.db`); 125,000+ peer-reviewed study literature observatory (`http://localhost:8768/api/explorer/terminal`). - **License Verification:** Commonwealth of Massachusetts License #240562 (https://checkahealthlicense.mass.gov/). - **NPI Registry:** 1962722637 (https://npiregistry.cms.hhs.gov/provider-view/1962722637). - **Ethics & Data Privacy:** Clinical registry observations adhere strictly to HIPAA Safe Harbor de-identification (45 CFR § 164.514(b)) and criteria for secondary research exemption under 45 CFR § 46.104(d)(4).