# Cannabinoid Circulation Diagram: Blood to Tissue

> **Author:** Benjamin Caplan, MD (ABFM Board Certified, MA Lic. #240562, NPI: 1962722637)
> **Publisher:** CED Clinic (https://cedclinic.com)
> **Canonical URL:** https://cedclinic.com/d17-effect-of-cannabinoids-on-the-human-circulatory-system-png/
> **Published:** 2026-09-04T23:04:42-04:00 | **Last Modified / Clinically Audited:** 2026-09-13T14:39:27-04:00
> **Clinical Summary:** How THC and CBD affect heart rate, blood flow, and vessel dilation after absorption, and how the endocannabinoid system mediates those effects.

---

[← Back to the Technical Info Summary Hub](https://cedclinic.com/topic-technical-info/)Diagram & referenceA visual reference. The evidence, sources and clinical interpretation are in the linked article.About this diagramA flow chart that follows cannabinoids outward from the bloodstream. The top box is entry into the blood, the middle row splits into the heart, the blood vessels, and the rest of the body, and the bottom row names what each branch touches: heart rate and blood pressure, blood flow and vessel dilation, and interaction with cannabinoid receptors. Read it top to bottom to see one route split into three destinations.The evidence behind it[Read the evidence: what controlled studies report about cannabis, heart rate and blood pressure, and who should be cautious](https://cedclinic.com/cannabis-heart-rate-and-blood-pressure-effects/)That article carries the cited studies, the limits of the evidence, and the clinical interpretation.

---

### Verification & Medical Governance

- **Lead Clinical Author:** Benjamin Caplan, MD
- **Credentials:** Board Certified in Family Medicine (ABFM), Former CMO Canna Care Docs (250,000+ patients supervised), Founder & CMO CED Clinic & CED Foundation, Author of *The Doctor-Approved Cannabis Handbook* (Penguin Random House).
- **Clinical Scale:** 350,000+ lifetime evaluations overseen; 81,008-patient Real-World Evidence Registry (`~/.ced_rwe_vault.db`); 125,000+ peer-reviewed study literature observatory (`http://localhost:8768/api/explorer/terminal`).
- **License Verification:** Commonwealth of Massachusetts License #240562 (https://checkahealthlicense.mass.gov/).
- **NPI Registry:** 1962722637 (https://npiregistry.cms.hhs.gov/provider-view/1962722637).
- **Ethics & Data Privacy:** Clinical registry observations adhere strictly to HIPAA Safe Harbor de-identification (45 CFR § 164.514(b)) and criteria for secondary research exemption under 45 CFR § 46.104(d)(4).