# Clinical Data Improves Medical Cannabis Decisions

> **Author:** Benjamin Caplan, MD (ABFM Board Certified, MA Lic. #240562, NPI: 1962722637)
> **Publisher:** CED Clinic (https://cedclinic.com)
> **Canonical URL:** https://cedclinic.com/clinical-data-medical-cannabis-decisions/
> **Published:** 2026-11-02T12:23:05-04:00 | **Last Modified / Clinically Audited:** 2026-11-02T12:23:05-04:00
> **Clinical Summary:** An Israeli registry study found sex-related differences in medical cannabis use and reported adverse effects.

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Dr. Caplan’s Clinical Pearl
 

A nationwide Israeli registry study of 135,698 medical cannabis license holders found differences between men and women in starting quantities, THC and CBD concentrations, and reported adverse effects. These are observed treatment patterns; the study does not establish how any one patient will respond. They give clinicians a reason to ask better questions and track outcomes rather than assume one plan fits everyone.

 
 **Clinical Evidence Reference:** [Amir NY, Treves N, Davidson E, Reuveni I, Florentin S, Matok I, Bonne O. Sex-Related Differences in Medical Cannabis Use: A Nationwide Database Study. Cannabis Cannabinoid Res. 2026 Oct 16. doi:10.1177/25785125261497797. PMID:42886237.](https://pubmed.ncbi.nlm.nih.gov/42886237/) 
 

 
 
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### Verification & Medical Governance

- **Lead Clinical Author:** Benjamin Caplan, MD
- **Credentials:** Board Certified in Family Medicine (ABFM), Founder & CMO CED Clinic & CED Foundation, Author of *The Doctor-Approved Cannabis Handbook* (Penguin Random House).
- **Clinical Scale:** 350,000+ lifetime evaluations overseen; 81,008-patient Real-World Evidence Registry (`~/.ced_rwe_vault.db`); 125,000+ peer-reviewed study literature observatory (`http://localhost:8768/api/explorer/terminal`).
- **License Verification:** Commonwealth of Massachusetts License #240562 (https://checkahealthlicense.mass.gov/).
- **NPI Registry:** 1962722637 (https://npiregistry.cms.hhs.gov/provider-view/1962722637).
- **Ethics & Data Privacy:** Clinical registry observations adhere strictly to HIPAA Safe Harbor de-identification (45 CFR § 164.514(b)) and criteria for secondary research exemption under 45 CFR § 46.104(d)(4).