# Pediatric Medicine Side Effect Comparison Chart

> **Author:** Benjamin Caplan, MD (ABFM Board Certified, MA Lic. #240562, NPI: 1962722637)
> **Publisher:** CED Clinic (https://cedclinic.com)
> **Canonical URL:** https://cedclinic.com/children-and-medical-cannabis-understanding-therapeutic-potentials-and-precautions/
> **Published:** 2026-09-04T23:01:08-04:00 | **Last Modified / Clinically Audited:** 2026-09-24T10:47:12-04:00
> **Clinical Summary:** Where medical cannabis has shown promise in pediatric care, where the evidence is thin, and the precautions families and clinicians should weigh first.

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[← Back to the Teens Summary Hub](https://cedclinic.com/topic-teens/)Diagram & referenceA visual reference. The evidence, sources and clinical interpretation are in the linked article.Prescription CBD (Epidiolex) in children: side effects reported in trialsSide effectHow often in trialsNotesSleepinessCommonMore likely alongside clobazamDecreased appetite, weight lossCommonMonitor weightDiarrheaCommonOften dose-relatedRaised liver enzymesOccasionalMore likely with valproate; blood tests before and during treatmentDrug interactionsImportantRaises clobazam levels; check other medicines with the prescriberBased on the Epidiolex prescribing information. Reviewed by Dr. Benjamin Caplan, MD.About this diagramA table of the side effects reported when children took prescription CBD (Epidiolex) in clinical trials, with how often each occurred and what families and prescribers watch for. It follows the drug’s prescribing information. What the pediatric trials do and do not show is covered in the article linked below.The evidence behind it[Read the evidence: where pediatric cannabinoid trials are strong, where they are thin, and where they do not exist](https://cedclinic.com/medical-cannabis-for-children-what-evidence-supports/)That article carries the cited studies, the limits of the evidence, and the clinical interpretation.

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### Verification & Medical Governance

- **Lead Clinical Author:** Benjamin Caplan, MD
- **Credentials:** Board Certified in Family Medicine (ABFM), Former CMO Canna Care Docs (250,000+ patients supervised), Founder & CMO CED Clinic & CED Foundation, Author of *The Doctor-Approved Cannabis Handbook* (Penguin Random House).
- **Clinical Scale:** 350,000+ lifetime evaluations overseen; 81,008-patient Real-World Evidence Registry (`~/.ced_rwe_vault.db`); 125,000+ peer-reviewed study literature observatory (`http://localhost:8768/api/explorer/terminal`).
- **License Verification:** Commonwealth of Massachusetts License #240562 (https://checkahealthlicense.mass.gov/).
- **NPI Registry:** 1962722637 (https://npiregistry.cms.hhs.gov/provider-view/1962722637).
- **Ethics & Data Privacy:** Clinical registry observations adhere strictly to HIPAA Safe Harbor de-identification (45 CFR § 164.514(b)) and criteria for secondary research exemption under 45 CFR § 46.104(d)(4).