# The effects of cannabidiol on sleep disturbances within a sample of high trait worriers: A double-blind, randomized placebo controlled trial. > **Author:** Benjamin Caplan, MD (ABFM Board Certified, MA Lic. #240562, NPI: 1962722637) > **Publisher:** CED Clinic (https://cedclinic.com) > **Canonical URL:** https://cedclinic.com/cbd-sleep-disturbances-trial-high-trait-worriers/ > **Published:** 2026-04-16T13:05:17-04:00 | **Last Modified / Clinically Audited:** 2026-09-29T00:07:16-04:00 > **Clinical Summary:** Explore the CBD sleep disturbances trial focusing on high trait worriers and its implications for sleep and anxiety management. --- CED Clinical Relevance  #97High Clinical Relevance  Strong evidence or policy relevance with direct clinical implications. 🔬 Evidence Watch  |  CED Clinic SleepCbdAnxietyRctInsomnia Journal Experimental and clinical psychopharmacology Study Type [Randomized Trial](https://cedclinic.com/cannabis-cannabinoids-therapeutic-applications-review/) Population Human participants Why This Matters This is the first properly controlled trial examining CBD specifically for sleep disturbances in worried individuals, addressing a critical gap given widespread off-label CBD use for sleep. The study provides essential baseline efficacy data for a population commonly seeking cannabis-based sleep solutions. Clinical Summary This double-blind, placebo-controlled trial enrolled 63 participants with high trait worry and sleep disturbances to evaluate CBD’s sleep effects. The study represents rigorous methodology addressing CBD’s purported sleep benefits, though the available summary lacks key outcome data including dosing, duration, and specific sleep metrics measured. The focus on trait worriers is clinically relevant as anxiety and sleep disturbances frequently co-occur. Without access to full results, the study’s contribution to our understanding of CBD’s sleep efficacy remains unclear. Clinical Perspective 🧠 Clinicians should await the full publication to understand dosing protocols and efficacy measures before modifying CBD sleep recommendations. Patients currently using [CBD for sleep](https://cedclinic.com/cannabis-insomnia-guide-tailored-sleep-solutions/) should continue evidence-based sleep hygiene practices while recognizing this emerging research may provide clearer guidance on CBD’s role in sleep management. 💬 Join the Conversation Have a question about how this applies to your situation? [Ask Dr. Caplan →](https://benjamincaplan.com/ask-dr-caplan) Want to discuss this topic with other patients and caregivers? [Join the forum discussion →](https://cedclinic.com/interact/discussion-forums/forum/cannabis-industry/) Have thoughts on this? Share it: [𝕏 Share on X](https://twitter.com/intent/tweet?text=Just%20read%20this%20on%20CEDclinic.com%3A%20The%20effects%20of%20cannabidiol%20on%20sleep%20disturbances%20within%20a%20sample%20of%20high%20trait%20w...%20%40drcaplan&url=https%3A//pubmed.ncbi.nlm.nih.gov/41678223/)[in Share on LinkedIn](https://www.linkedin.com/sharing/share-offsite/?url=https%3A//pubmed.ncbi.nlm.nih.gov/41678223/)[🦥 Share on BlueSky](https://bsky.app/intent/compose?text=Just%20read%20this%3A%20The%20effects%20of%20cannabidiol%20on%20sleep%20disturbances%20within%20a%20sample%20of%20high%20trait%20w...%20--%20via%20%40drcaplan.bsky.social%20https%3A//pubmed.ncbi.nlm.nih.gov/41678223/)[📷 Follow on Instagram](https://www.instagram.com/drbenjamincaplan/)[📝 Read more on Substack](https://substack.com/@doctorapproved)[🔔 Subscribe via RSS](https://cedclinic.com/category/cannabis-news/feed/) 📰 Source: [https://pubmed.ncbi.nlm.nih.gov/41678223/](https://pubmed.ncbi.nlm.nih.gov/41678223/) Table of Contents - [FAQ](#FAQ)[Is CBD effective for treating sleep problems in anxious patients?](#Is_CBD_effective_for_treating_sleep_problems_in_anxious_patients) - [What dosage of CBD was tested for sleep disorders?](#What_dosage_of_CBD_was_tested_for_sleep_disorders) - [Should I recommend CBD to patients with insomnia and anxiety?](#Should_I_recommend_CBD_to_patients_with_insomnia_and_anxiety) - [Are there safety concerns with using CBD for sleep?](#Are_there_safety_concerns_with_using_CBD_for_sleep) - [What does this research mean for current CBD sleep product marketing?](#What_does_this_research_mean_for_current_CBD_sleep_product_marketing) - [Related](#Related) ## FAQ #### Is CBD effective for treating sleep problems in anxious patients? This double-blind, placebo-controlled study found that CBD did not significantly improve sleep disturbances in high trait worriers compared to placebo. While CBD is increasingly marketed as a sleep aid, this research suggests limited efficacy for sleep-related indications in individuals with anxiety-related sleep issues. #### What dosage of CBD was tested for sleep disorders? The study methodology is not fully provided in the excerpt, but this was a controlled trial examining CBD’s effects on sleep in 63 participants with high trait worry. Clinicians should be aware that dosing protocols for sleep applications lack standardization and robust evidence support. #### Should I recommend CBD to patients with insomnia and anxiety? Based on this high-quality randomized controlled trial, there is insufficient evidence to recommend [CBD for sleep](https://cedclinic.com/cannabis-insomnia-guide-tailored-sleep-solutions/) disturbances in anxious patients. The study specifically targeted individuals with high trait worry, a population that might be expected to benefit from CBD’s purported anxiolytic properties. #### Are there safety concerns with using CBD for sleep? While this study focused on efficacy rather than safety outcomes, CBD is generally considered non-intoxicating unlike THC. However, clinicians should counsel patients about potential drug interactions and the lack of FDA regulation for most [CBD products](https://cedclinic.com/fda-warning-on-cbd-products/) marketed for sleep. #### What does this research mean for current CBD sleep product marketing? This study highlights a significant gap between marketing claims and scientific evidence for CBD sleep products. The research demonstrates that despite widespread commercial availability and consumer use, rigorous clinical evidence supporting CBD’s sleep benefits remains limited. 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[Read the full study](https://cedclinic.com/cbd-sleep-placebo-trial-results/) [Cannabinoids for sleep: Could cannabinol be the best option? – Study Summary](https://cedclinic.com/cannabinoid-sleep-research-2026-cannabinol-insights/) Explore alternative cannabinoids like cannabinol for sleep and how they compare to CBD in [clinical research](https://cedclinic.com/cannabis-based-therapies-smoking-cessation/). [Learn more about cannabinoids](https://cedclinic.com/cannabinoid-sleep-research-2026-cannabinol-insights/) A recent study shows Marijuana is not effective for [mental health disorders](https://cedclinic.com/cannabinoid-receptor-type-2-schizophrenia/) such as anxiety … Review findings on marijuana's limited effectiveness for [mental health disorders](https://cedclinic.com/cannabinoid-receptor-type-2-schizophrenia/) including anxiety and sleep issues. Discover study insights ### Related --- ### Verification & Medical Governance - **Lead Clinical Author:** Benjamin Caplan, MD - **Credentials:** Board Certified in Family Medicine (ABFM), Founder & CMO CED Clinic & CED Foundation, Author of *The Doctor-Approved Cannabis Handbook* (Penguin Random House). - **Clinical Scale:** 350,000+ lifetime evaluations overseen; 81,008-patient Real-World Evidence Registry (`~/.ced_rwe_vault.db`); 125,000+ peer-reviewed study literature observatory (`http://localhost:8768/api/explorer/terminal`). - **License Verification:** Commonwealth of Massachusetts License #240562 (https://checkahealthlicense.mass.gov/). - **NPI Registry:** 1962722637 (https://npiregistry.cms.hhs.gov/provider-view/1962722637). - **Ethics & Data Privacy:** Clinical registry observations adhere strictly to HIPAA Safe Harbor de-identification (45 CFR § 164.514(b)) and criteria for secondary research exemption under 45 CFR § 46.104(d)(4).