# The Effectiveness of CBD and CBN in the Treatment of Facial Pain and Headache of Muscular Origin > **Author:** Benjamin Caplan, MD (ABFM Board Certified, MA Lic. #240562, NPI: 1962722637) > **Publisher:** CED Clinic (https://cedclinic.com) > **Canonical URL:** https://cedclinic.com/cbd-cbn-combination-chronic-facial-pain-clinical-trial-review/ > **Published:** 2026-05-08T15:05:16-04:00 | **Last Modified / Clinically Audited:** 2026-09-28T17:15:57-04:00 > **Clinical Summary:** Clinical trial evaluates CBD CBN combination for chronic facial pain using objective measures. Dr. Caplan reviews this promising muscle pain research. --- CED Clinical Relevance  #82High Clinical Relevance  Strong evidence or policy relevance with direct clinical implications. 🧪 [Clinical Trial](https://cedclinic.com/marijuana-reclassification-impact-cannabis-companies/) Watch  |  CED Clinic Trial ID NCT05961501 Status Enrolling By Invitation Condition Myalgia Intervention An aqueous solution containing CBD and CBN Why This Matters Facial pain and headaches of muscular origin affect millions but lack standardized treatment protocols. This trial addresses a critical gap by evaluating specific cannabinoid combinations using objective electromyographic measurements rather than subjective pain scales alone. [Clinical Summary](https://cedclinic.com/recreational-marijuana-legalization-24-states-update/) This randomized, double-blind, placebo-controlled trial enrolls 42 adults with chronic (>3 months) facial pain and headache of muscular origin. Participants receive either an aqueous CBD/CBN solution or placebo for 60 days, with outcomes measured via electromyography, pressure pain threshold testing, and clinical examination at baseline, day 20, 40, and 60. The trial is currently enrolling by invitation and represents one of the first controlled studies examining this specific cannabinoid combination for myofascial pain. Dr. Caplan’s Take “If positive, this trial could provide the evidence base I need to confidently recommend specific CBD/CBN formulations for patients with chronic facial myalgia. The objective EMG endpoints are particularly valuable for establishing [clinical credibility](https://cedclinic.com/academic-misconduct-cannabis-research-raleigh-hemp-case/).” [Clinical Perspective](https://cedclinic.com/religious-beliefs-cannabis-use-clinical-perspectives/) 🧠 Patients with chronic facial pain should understand this represents early-stage research with invitation-only enrollment. The 60-day timeline and objective muscle function measurements suggest rigorous methodology, though results won’t be available for clinical application for several years. 💬 Join the Conversation Have a question about how this applies to your situation? [Ask Dr. Caplan →](https://benjamincaplan.com/ask-dr-caplan) Want to discuss this topic with other patients and caregivers? [Join the forum discussion →](https://cedclinic.com/interact/discussion-forums/forum/cannabis-industry/) Have thoughts on this? Share it: [𝕏 Share on X](https://twitter.com/intent/tweet?text=Just%20read%20this%20on%20CEDclinic.com%3A%20The%20Effectiveness%20of%20CBD%20and%20CBN%20in%20the%20Treatment%20of%20Facial%20Pain%20and%20Headache%20of...%20%40drcaplan&url=https%3A//clinicaltrials.gov/study/NCT05961501)[in Share on LinkedIn](https://www.linkedin.com/sharing/share-offsite/?url=https%3A//clinicaltrials.gov/study/NCT05961501)[🦥 Share on BlueSky](https://bsky.app/intent/compose?text=Just%20read%20this%3A%20The%20Effectiveness%20of%20CBD%20and%20CBN%20in%20the%20Treatment%20of%20Facial%20Pain%20and%20Headache%20of...%20--%20via%20%40drcaplan.bsky.social%20https%3A//clinicaltrials.gov/study/NCT05961501)[📷 Follow on Instagram](https://www.instagram.com/drbenjamincaplan/)[📝 Read more on Substack](https://substack.com/@doctorapproved)[🔔 Subscribe via RSS](https://cedclinic.com/category/cannabis-news/feed/) 📰 Source: [https://clinicaltrials.gov/study/NCT05961501](https://clinicaltrials.gov/study/NCT05961501) Table of Contents - [FAQ](#FAQ)[What is the CBD and CBN facial pain trial testing?](#What_is_the_CBD_and_CBN_facial_pain_trial_testing) - [Who is taking part in the CBD and CBN facial pain trial?](#Who_is_taking_part_in_the_CBD_and_CBN_facial_pain_trial) - [How will researchers measure whether CBD and CBN reduce muscle-related facial pain?](#How_will_researchers_measure_whether_CBD_and_CBN_reduce_muscle-related_facial_pain) - [Are results from this CBD and CBN trial available yet?](#Are_results_from_this_CBD_and_CBN_trial_available_yet) - [Related](#Related) ## FAQ ### What is the CBD and CBN facial pain trial testing? The trial is testing an aqueous solution containing CBD and CBN for chronic facial pain and headache of muscular origin. It is randomized, double-blind, and placebo-controlled: participants receive either the CBD/CBN solution or a placebo for 60 days. It is registered as NCT05961501, with myalgia listed as the condition. ### Who is taking part in the CBD and CBN facial pain trial? The trial enrolls 42 adults whose facial pain and headache of muscular origin has lasted more than three months. Enrollment is by invitation rather than open recruitment. The trial is described as one of the first controlled studies examining this specific cannabinoid combination for myofascial pain. ### How will researchers measure whether CBD and CBN reduce muscle-related facial pain? Outcomes are measured with electromyography, which records muscle activity, along with pressure pain threshold testing and clinical examination. These assessments take place at baseline and on days 20, 40, and 60. The trial relies on objective electromyographic measurements rather than subjective pain scales alone. ### Are results from this CBD and CBN trial available yet? Not yet. The trial is currently enrolling by invitation, so it is still under way and no findings are reported. Whether the CBD and CBN solution works better than placebo for facial pain and headache of muscular origin will only be known once the 60-day treatment results are analyzed. [https://cedclinic.com/contact/](https://cedclinic.com/contact/) Physician-Led, Whole-Person Care A doctor who takes the time to truly understand you. Personal care that starts with listening and is guided by experience and ingenuity. Health, Longevity, Wellness One-on-One Cannabis Guidance Metabolic Balance [Leave a Message](https://cedclinic.com/contact/) [Metabolic Care](https://cedclinic.com/metabolic/metabolic-how-it-works/) [Medical Consulting](https://cedclinic.com/book/) [Cannabis Care](https://cedclinic.com/book/) [https://cedclinic.com/contact/](https://cedclinic.com/contact/) ### Related --- ### Verification & Medical Governance - **Lead Clinical Author:** Benjamin Caplan, MD - **Credentials:** Board Certified in Family Medicine (ABFM), Founder & CMO CED Clinic & CED Foundation, Author of *The Doctor-Approved Cannabis Handbook* (Penguin Random House). - **Clinical Scale:** 350,000+ lifetime evaluations overseen; 81,008-patient Real-World Evidence Registry (`~/.ced_rwe_vault.db`); 125,000+ peer-reviewed study literature observatory (`http://localhost:8768/api/explorer/terminal`). - **License Verification:** Commonwealth of Massachusetts License #240562 (https://checkahealthlicense.mass.gov/). - **NPI Registry:** 1962722637 (https://npiregistry.cms.hhs.gov/provider-view/1962722637). - **Ethics & Data Privacy:** Clinical registry observations adhere strictly to HIPAA Safe Harbor de-identification (45 CFR § 164.514(b)) and criteria for secondary research exemption under 45 CFR § 46.104(d)(4).