# 5 Reasons CBD CBG Topicals For Eczema Care is Amazing > **Author:** Benjamin Caplan, MD (ABFM Board Certified, MA Lic. #240562, NPI: 1962722637) > **Publisher:** CED Clinic (https://cedclinic.com) > **Canonical URL:** https://cedclinic.com/cbd-cbg-topicals-for-eczema/ > **Published:** 2025-04-04T11:54:19-04:00 | **Last Modified / Clinically Audited:** 2026-09-13T19:23:22-04:00 > **Clinical Summary:** 5 science-backed benefits of CBD and CBG topicals for eczema. Learn why combining CBG and CBD enhances anti-inflammatory skin barrier care. --- Table of Contents - [CBD CBG Topicals for Eczema: 5 Proven Benefits Backed by Data](#CBD_CBG_Topicals_for_Eczema_5_Proven_Benefits_Backed_by_Data) - [Tl;DR (Top 5 Takeaways)](#TlDR_Top_5_Takeaways) - [Can Cannabinoids Calm the Storm of Atopic Dermatitis?](#Can_Cannabinoids_Calm_the_Storm_of_Atopic_Dermatitis) - [What Did the CBD CBG Topical for Eczema Actually Do?](#What_Did_the_CBD_CBG_Topical_for_Eczema_Actually_Do)[Results Worth Scratching Into the Record](#Results_Worth_Scratching_Into_the_Record) - [What’s Working Behind the Scenes?](#Whats_Working_Behind_the_Scenes)[The Endocannabinoid System—Not Just for Mood Swings](#The_Endocannabinoid_SystemNot_Just_for_Mood_Swings) - [Why You Shouldn’t Toss Your Steroids Just Yet](#Why_You_Shouldn8217t_Toss_Your_Steroids_Just_Yet)[It’s a Pilot Study, Not a Prescription](#It8217s_a_Pilot_Study_Not_a_Prescription) - [Humor Me—Why This Matters Beyond the Numbers](#Humor_MeWhy_This_Matters_Beyond_the_Numbers) - [What Should Clinicians and Patients Take Away?](#What_Should_Clinicians_and_Patients_Take_Away)[Clinicians](#Clinicians) - [Patients](#Patients) - [Where This Goes Next](#Where_This_Goes_Next) - [Internal Resources to Explore](#Internal_Resources_to_Explore) - [External Resources Worth Bookmarking](#External_Resources_Worth_Bookmarking) - [Why Combining CBG with CBD Enhances Anti-Inflammatory Action](#Why_Combining_CBG_with_CBD_Enhances_Anti-Inflammatory_Action) - [How to Apply Cannabinoid Creams for Optimal Skin Barrier Absorption](#How_to_Apply_Cannabinoid_Creams_for_Optimal_Skin_Barrier_Absorption)[Related](#Related) ## CBD CBG Topicals for Eczema: 5 Proven Benefits Backed by Data What one tiny [More access here](https://cedclinic.com/) taught us about high-dose cannabinoids and itchy, angry skin. A 2025 pilot study titled *“Evaluation of Biophysical Parameters of the Skin of Patients With Atopic Dermatitis After Application of an Ointment Containing 30% Cannabidiol and 5% Cannabigerol”* by Burczyk et al., published in *Clinical, Cosmetic and Investigational Dermatology* (DOI: [10.2147/CCID.S472746](https://doi.org/10.2147/CCID.S472746)), set out to explore whether a cannabinoid-rich ointment could bring real relief to patients battling the chronic discomfort of atopic dermatitis. Or [More access here](https://cedclinic.com/) here   ## Tl;DR (Top 5 Takeaways)   - A potent CBD-CBG topical showed measurable improvements in hydration, barrier repair, and inflammation for AD patients. - Despite encouraging skin metrics, the study’s sample size was small and lacked a control group. - The formulation included 30% CBD and 5% CBG—a high dose not commonly found in over-the-counter products. - Cannabinoids’ skin benefits may come from anti-inflammatory and ECS-modulating properties. - More robust trials are needed before declaring this formulation a game-changer—but it’s a promising start. Could cannabinoids restore balance to damaged skin? ## Can Cannabinoids Calm the Storm of Atopic Dermatitis? Atopic dermatitis (AD), that irritating skin circus of redness, itching, and frustration, has long bullied the lotions and potions aisle. Enter: a CBD CBG topical for eczema—part science experiment, part hopeful balm. This recent pilot study, published in *Clinical, Cosmetic and Investigational Dermatology*, puts cannabinoids on trial in a serious skin showdown. While it’s not the silver bullet (yet), the study packs plenty of punch—offering evidence, curiosity, and just a dash of “what if?” Let’s peel it all back.   The study used a 30% CBD and 5% CBG ointment. **What Was This Study About?** It wasn’t a full-blown randomized controlled trial (RCT)—think more dermatological reconnaissance mission. **The Details** - **Location:** Medical University of Silesia, Poland - **Sample Size:** Just 9 patients (20–67 years old) - **Study Type:** Single-center, open-label, no control - **Ointment Composition:** 30% Cannabidiol (CBD) - 5% Cannabigerol (CBG) - Hemp seed oil - Cholesterol-based emollient base **Application:** Once daily on the forearms for 8 weeks, wrapped overnight with wet dressings. Think of it as a bedtime ritual for your eczema—minus the fairy dust. [https://www.sciencedirect.com/science/article/abs/pii/S0006295218303484](https://www.sciencedirect.com/science/article/abs/pii/S0006295218303484)[Cannabinoid receptors](https://cedclinic.com/citral-cannabinoid-receptor-2-activation-pain-relief/) CB1 and CB2 play key roles in skin health ## What Did the CBD CBG Topical for Eczema Actually Do? ### Results Worth Scratching Into the Record Measured skin changes over 8 weeks included: - **↑ Skin Hydration** (p < 0.001) - **↓ Transepidermal Water Loss (TEWL)** (p < 0.001) - **↑ Sebum Levels** (p < 0.05) - **↓ Erythema (redness)** (p < 0.01) Notably, **skin pH** and **melanin levels** didn’t budge significantly—so, no, this won’t double as a tanning lotion. These aren’t just vanity metrics. Hydration and reduced TEWL signal better **barrier function**, a central struggle in AD. A complex system still largely unexplored by science ## What’s Working Behind the Scenes? ### The Endocannabinoid System—Not Just for Mood Swings The body’s **[endocannabinoid system](https://cedclinic.com/endocannabinoid-system-fear-extinction/) (ECS)** is like your internal conductor—regulating inflammation, pain, even itch perception. Cannabinoid receptors (CB1 and CB2) live in your **skin cells, immune cells, and sebaceous glands**, meaning topicals don’t need to reach the bloodstream to get to work. **CBD** steps in as the chill diplomat: - Stabilizes mast cells (→ less histamine itch) - Calms inflammation - Boosts barrier restoration **CBG**, meanwhile, is like the bouncer at the cytokine club: - Suppresses pro-inflammatory cytokines - Fights off staph and other skin-invading bacteria - Inhibits arachidonic acid, a player in inflammation Not quite ready to replace steroids—but maybe someday? ## Why You Shouldn’t Toss Your Steroids Just Yet #### It’s a Pilot Study, Not a Prescription Let’s be clear: This was a **tiny**, non-blinded, non-randomized study with **no control group**. Some participants bailed early. Others didn’t love the ointment’s greasy texture. And critically—it was run during **May to July**, when AD tends to chill out naturally. Still, improvements in hydration and inflammation weren’t just a fluke. The numbers were statistically significant, and in some cases—like Patient #4’s hydration jumping from 6.5 to 22.4 CU—**visibly impressive**. Study participants saw reduced redness and improved barrier function. ## Humor Me—Why This Matters Beyond the Numbers Because chronic skin conditions mess with more than just your dermis. They poke at your self-esteem, your sleep, your dating life, your sanity. And let’s face it: **steroid creams** often feel like both salvation and sabotage. Enter a **CBD CBG topical for eczema**, promising relief without the hormone rollercoaster. Is it magic? Nope. Is it worth exploring further, especially with physician guidance? Absolutely. ## What Should Clinicians and Patients Take Away? ### Clinicians - Educate patients about **CBD dosing realism**—this ointment was 30%, not 3%. - Emphasize that **topical ECS targeting is real**, but **regulatory and product inconsistency** make [patient counseling](https://cedclinic.com/stroke-risk-assessment-substance-use/) essential. - Consider **pilot use** in steroid-weary or side-effect-sensitive patients, especially if [quality of life](https://cedclinic.com/cannabis-policy-enforcement-february-26-2026/) is tanking. ### Patients - Look for **high-quality formulations**. Over-the-counter “CBD creams” often don’t list CBG or even CBD concentrations. - Talk to your provider, especially if you’re juggling other dermatologic or immune conditions. - Manage expectations—it’s relief, not a resurrection. ## Where This Goes Next More studies. Larger sample sizes. RCTs with longer follow-ups. Maybe even a double-blind trial using **a head-to-head against hydrocortisone**. Until then? The PDF is available [here](https://doi.org/10.2147/CCID.S472746) if you’re the type who likes combing through tables and graphs. And for clinicians and patients alike, let this be a **nudge** toward better cannabinoid dermatology research—grounded in data, driven by curiosity, and guided by people who know skin better than a TikTok influencer with a jade roller. ## Internal Resources to Explore - [Medical Cannabis for Chronic Inflammation](https://cedclinic.com/chronic-pain-inflammation/) - [Understanding the Endocannabinoid System](https://cedclinic.com/deep-dive-the-expanded-endocannabinoid-system/) - [How to Talk to Your Doctor About Cannabis](https://cedclinic.com/talk-to-your-doctor-about-weed/) ## External Resources Worth Bookmarking   - [National Eczema Association Commentary ](https://nationaleczema.org/blog/can-marijuana-help/) - [The Skin and Natural Cannabinoids–Topical and Transdermal Applications](https://pmc.ncbi.nlm.nih.gov/articles/PMC10386449/) - [What Are The Unique Cannabinoids? ](https://cedclinic.com/resources/awesome-extras/unique-cannibinoids/)   ### ## Why Combining CBG with CBD Enhances Anti-Inflammatory Action Cannabigerol (CBG) possesses distinct antibacterial and anti-inflammatory properties that complement Cannabidiol (CBD). When formulated together in topical salves, they act synergistically on cutaneous cannabinoid receptors to reduce itching, redness, and keratinocyte inflammation in eczema-prone skin. ## How to Apply Cannabinoid Creams for Optimal Skin Barrier Absorption Apply topical formulations to clean, slightly damp skin twice daily. Massage gently until absorbed to allow lipophilic cannabinoids to penetrate the epidermal barrier effectively. ### Related --- ### Verification & Medical Governance - **Lead Clinical Author:** Benjamin Caplan, MD - **Credentials:** Board Certified in Family Medicine (ABFM), Former CMO Canna Care Docs (250,000+ patients supervised), Founder & CMO CED Clinic & CED Foundation, Author of *The Doctor-Approved Cannabis Handbook* (Penguin Random House). - **Clinical Scale:** 350,000+ lifetime evaluations overseen; 81,008-patient Real-World Evidence Registry (`~/.ced_rwe_vault.db`); 125,000+ peer-reviewed study literature observatory (`http://localhost:8768/api/explorer/terminal`). - **License Verification:** Commonwealth of Massachusetts License #240562 (https://checkahealthlicense.mass.gov/). - **NPI Registry:** 1962722637 (https://npiregistry.cms.hhs.gov/provider-view/1962722637). - **Ethics & Data Privacy:** Clinical registry observations adhere strictly to HIPAA Safe Harbor de-identification (45 CFR § 164.514(b)) and criteria for secondary research exemption under 45 CFR § 46.104(d)(4).