# Cannabis Pumpkin Spice Cupcakes Recipe > **Author:** Benjamin Caplan, MD (ABFM Board Certified, MA Lic. #240562, NPI: 1962722637) > **Publisher:** CED Clinic (https://cedclinic.com) > **Canonical URL:** https://cedclinic.com/cannabis-pumpkin-spice-cupcakes-recipe/ > **Published:** 2023-08-03T01:41:04-04:00 | **Last Modified / Clinically Audited:** 2026-10-27T14:51:22-04:00 > **Clinical Summary:** Bake seasonal cannabis pumpkin spice cupcakes with Dr. Caplan's zero-heat frosting infusion method for exact dosing and complete terpene preservation. --- Doctor-Approved Culinary MedicineInfused Pumpkin Cupcakes: Frosting Infusion & Baking Heat **Baking thermodynamics & dosing:** When baking infused cupcakes, the smartest clinical technique is infusing the cream cheese frosting rather than the baked cupcake batter. Dr. Benjamin Caplan explains: (1) Off-Heat Frosting Infusion—whipping room-temperature cannabutter directly into cream cheese and powdered sugar involves zero heat exposure, preserving 100% of cannabinoids and delicate aromatic terpenes; (2) Batter Moisture Buffer—if infusing the cupcake batter itself, the pumpkin puree and moisture create an internal steam shield maintaining cake interior temperatures near 210°F (99°C) during a 350°F bake; and (3) Precise Portioning—using a standardized piping tip or cookie scoop allows you to distribute identical frosting portions across each cupcake (e.g., using 60 mg total THC across 12 cupcakes delivers exactly 5 mg per cupcake). **Culinary rules:** Infuse the Frosting for Zero Heat Loss • Pumpkin Puree Thermal Shield • Scoop Frosting for Equal Doses • Refrigerate Cream Cheese Frosting Dietary Labels Nut-FreeCaffeine-FreeAlcohol-Free Table of Contents - [Ingredients](#Ingredients) - [Directions](#Directions) - [Frequently Asked Questions: Cannabis Pumpkin Spice Cupcakes](#Frequently_Asked_Questions_Cannabis_Pumpkin_Spice_Cupcakes)[Why is it better to infuse the frosting instead of the batter?](#Why_is_it_better_to_infuse_the_frosting_instead_of_the_batter) - [Does baking cupcakes destroy THC in the batter?](#Does_baking_cupcakes_destroy_THC_in_the_batter) - [How do I ensure equal dosing per cupcake?](#How_do_I_ensure_equal_dosing_per_cupcake) - [How should leftover infused cupcakes be stored?](#How_should_leftover_infused_cupcakes_be_stored) - [Explore More Essential Infused Kitchen Recipes](#Explore_More_Essential_Infused_Kitchen_Recipes) - [Personalized Cannabinoid Care with Dr. Benjamin Caplan](#Personalized_Cannabinoid_Care_with_Dr_Benjamin_Caplan) - [Related](#Related) ### Ingredients - 4 eggs - 1 cup white sugar - ½ cup brown sugar, packed - 1 ¼ cups grapeseed oil - ¼ cup canna-oil - 2 tsp vanilla extract - 1 ¾ cups pure pumpkin puree - 3 cups all-purpose flour - 1 tbsp ground cinnamon - 1 tbsp pumpkin spice - 2 tsp baking powder - 2 tsp baking soda - 1 tbsp orange zest, optional ### Directions - Preheat the oven to 350°F/175°C. Line a jumbo muffin tin with liners. - Place the eggs, white sugar, brown sugar, grapeseed oil & canna-oil into a bowl fitted for a stand mixer or use a whisk to thoroughly beat ingredients together. - Blend in the pumpkin & vanilla extract. - In a small bowl mix the dry ingredients together. Add to the wet ingredients & mix until just blended. Stir in the orange zest (optional). - Divide the batter evenly between 12 muffin cups using a muffin scoop, about 3 ounces each. Sprinkle with pumpkin seeds. - Bake for 22–25 minutes or until a toothpick inserted into the middle comes out clean. ​ - Allow to cool, remove from the tins & sprinkle with cinnamon. [This recipe is available for download HERE](https://www.cedclinic.com/uploads/1/3/0/4/130464926/pumpkin_spice_muffins__1_.pdf) [*Original recipe from myedibleschef.com*](https://myedibleschef.com/recipes/pumpkin-spice-marijuana-muffins/) ### Frequently Asked Questions: Cannabis Pumpkin Spice Cupcakes #### Why is it better to infuse the frosting instead of the batter? Whipping cannabutter into frosting avoids all oven heat, preserving delicate terpenes and cannabinoids with zero thermal degradation. #### Does baking cupcakes destroy THC in the batter? No. Pumpkin puree and cake moisture keep the internal core temperature around 210°F (99°C), safely below cannabinoid degradation thresholds. #### How do I ensure equal dosing per cupcake? Use a standardized cookie scoop to measure batter into muffin cups and a piping bag or measured spoon for the infused frosting. #### How should leftover infused cupcakes be stored? Because cream cheese frosting is perishable, store in an airtight container in the refrigerator for up to 5 days, or freeze unfrosted cupcakes for up to 3 months. Doctor-Approved Culinary Medicine #### Explore More Essential Infused Kitchen Recipes - [Cannabis Rice Krispie Treats](https://cedclinic.com/cannabis-rice-krispie-treats-recipe/) — Gentle marshmallow melting and pan slicing math. - [Cannabis Pumpkin Spice Cupcakes](https://cedclinic.com/cannabis-pumpkin-spice-cupcakes-recipe/) — Infused cream cheese frosting and baking thermodynamics. - [Clarified Cannabutter Foundation](https://cedclinic.com/cannabis-butter-recipe/) — Water-bath thermal control preventing terpene degradation. - [Cannabis Blueberry Pie](https://cedclinic.com/cannabis-blueberry-pie-recipe/) — Double-crust pastry insulation and antioxidant pairings. - [Cannabis-Infused Peanut Butter](https://cedclinic.com/cannabis-infused-peanut-butter-recipe/) — High-shear lipid suspension and bio-availability. Doctor-Approved Medical Guidance ### Personalized Cannabinoid Care with Dr. Benjamin Caplan Cannabinoid therapy works best when tailored to your medical history, current medications, and symptom profile. Consult directly with Dr. Benjamin Caplan, MD, founder of CED Clinic and author of *The Doctor-Approved Cannabis Handbook*. [Book a Telehealth Consultation](https://cedclinic.com/contact/)[Explore Dr. Caplan’s Book](https://amzn.to/4a35lhE) ### Related --- ### Verification & Medical Governance - **Lead Clinical Author:** Benjamin Caplan, MD - **Credentials:** Board Certified in Family Medicine (ABFM), Founder & CMO CED Clinic & CED Foundation, Author of *The Doctor-Approved Cannabis Handbook* (Penguin Random House). - **Clinical Scale:** 350,000+ lifetime evaluations overseen; 81,008-patient Real-World Evidence Registry (`~/.ced_rwe_vault.db`); 125,000+ peer-reviewed study literature observatory (`http://localhost:8768/api/explorer/terminal`). - **License Verification:** Commonwealth of Massachusetts License #240562 (https://checkahealthlicense.mass.gov/). - **NPI Registry:** 1962722637 (https://npiregistry.cms.hhs.gov/provider-view/1962722637). - **Ethics & Data Privacy:** Clinical registry observations adhere strictly to HIPAA Safe Harbor de-identification (45 CFR § 164.514(b)) and criteria for secondary research exemption under 45 CFR § 46.104(d)(4).