# The Relationship Between Cannabis and Nicotine may Reveal Novel Treatments > **Author:** Benjamin Caplan, MD (ABFM Board Certified, MA Lic. #240562, NPI: 1962722637) > **Publisher:** CED Clinic (https://cedclinic.com) > **Canonical URL:** https://cedclinic.com/cannabis-nicotine-cognitive-effects-novel-treatments/ > **Published:** 2020-08-04T13:57:33-04:00 | **Last Modified / Clinically Audited:** 2026-09-28T11:17:27-04:00 > **Clinical Summary:** Explore cannabis nicotine cognitive effects and their potential to reveal novel treatments for sensory and cognitive process dysregulation. --- **Acute separate and combined effects of cannabinoid and nicotinic receptor agonists on MMN-indexed auditory deviance detection in healthy humans** In Summary Researchers have attempted to elucidate the relationship between nicotine and cannabis revealing a possible benefit for sensory and cognitive processes. A cannabinoid receptor 1 (CB1) agonist, nabilone, and nicotine were compared against each other and combined and compared with a placebo, resulting in the region and deviant-dependent effects. Temporal regions of the brain were not affected by coadministration of nabilone and nicotine, while frontal regions showed improved [cognitive function](https://cedclinic.com/reverse-cholesterol-transport-function-cannabis-users/). Future research should continue to develop therapies that combine CB1 agonists while minimizing the need for nicotine in order to develop therapies for the dysregulation of sensory and cognitive processes. So little is still understood about the interactions of the [endocannabinoid system](https://cedclinic.com/endocannabinoid-system-fear-extinction/), nicotinic receptors, and the opioid system. If the mechanisms underlying these various systems were well understood perhaps novel therapies could be developed to aid in the treatment of substance abuse disorders. Cannabis poses much less risk for addiction than opioids or nicotine as cannabis does not enact upon the reward system. Cannabis holds promise to lessen the troubles associated with the opioid academic by treating current addicts and preventing future addiction by serving as an adjunct therapy. Further research is needed to validate these hypotheses, but the current data provides hope for more ethical treatment methods. The study is available for review or download here: [DOWNLOAD & REVIEW HERE](https://www.cedfoundation.com/wp-content/uploads/2020/03/Acute-separate-and-combined-effects-of-cannabinoid-and-nicotinic-receptor-agonists-on-MMN-indexed-auditory-deviance-detection-in-healthy-humans.pdf) View more studies like this in the CED Foundation Archive: [http://bit.ly/drcaplan](http://bit.ly/drcaplan) [https://cedclinic.com/contact/](https://cedclinic.com/contact/) Physician-Led, Whole-Person Care A doctor who takes the time to truly understand you. Personal care that starts with listening and is guided by experience and ingenuity. Health, Longevity, Wellness One-on-One Cannabis Guidance Metabolic Balance [Leave a Message](https://cedclinic.com/contact/) [Metabolic Care](https://cedclinic.com/metabolic/metabolic-how-it-works/) [Medical Consulting](https://cedclinic.com/book/) [Cannabis Care](https://cedclinic.com/book/) [https://cedclinic.com/contact/](https://cedclinic.com/contact/) RELATED READING AT CED CLINIC Continue exploring the evidence [Endocannabinoid System Research: Cannabis Mental Health Care](https://cedclinic.com/clinical-trial-cannabis-mental-health-research/) Explore the role of the [endocannabinoid system](https://cedclinic.com/endocannabinoid-system-fear-extinction/) in [mental health](https://cedclinic.com/cannabis-psychiatric-research-findings-depression-anxiety/) and how [cannabis research](https://cedclinic.com/pediatric-cannabis-certification-care-children/) is advancing care. [Learn More](https://cedclinic.com/clinical-trial-cannabis-mental-health-research/) [Cannabinoid Clinical Trials: Mental Health Evidence Review](https://cedclinic.com/cannabinoid-clinical-trials-mental-health-evidence-review/) Review clinical trial evidence on cannabinoids and their impact on [mental health](https://cedclinic.com/cannabis-psychiatric-research-findings-depression-anxiety/) treatments. [Read Review](https://cedclinic.com/cannabinoid-clinical-trials-mental-health-evidence-review/) [Endocannabinoid System in Mental Health Treatment Research](https://cedclinic.com/endocannabinoid-system-mental-health-research/) Discover research on the endocannabinoid system's role in mental health treatment advancements. [Explore Research](https://cedclinic.com/endocannabinoid-system-mental-health-research/) Have thoughts on this? Share it: [X Share on X](https://twitter.com/intent/tweet?text=The%20Relationship%20Between%20Cannabis%20and%20Nicotine%20may%20Reveal%20Novel%20Treatments&url=https%3A%2F%2Fcedclinic.com%2Fcannabis-nicotine-cognitive-effects-novel-treatments%2F) [in Share on LinkedIn](https://www.linkedin.com/sharing/share-offsite/?url=https%3A%2F%2Fcedclinic.com%2Fcannabis-nicotine-cognitive-effects-novel-treatments%2F) [Share on BlueSky](https://bsky.app/intent/compose?text=The%20Relationship%20Between%20Cannabis%20and%20Nicotine%20may%20Reveal%20Novel%20Treatments%20https%3A%2F%2Fcedclinic.com%2Fcannabis-nicotine-cognitive-effects-novel-treatments%2F) [Follow on Instagram](https://www.instagram.com/drbenjamincaplan) [Read more on Substack](https://doctorapprovedcannabis.substack.com/) [Subscribe via RSS](https://cedclinic.com/feed/) ### Related --- ### Verification & Medical Governance - **Lead Clinical Author:** Benjamin Caplan, MD - **Credentials:** Board Certified in Family Medicine (ABFM), Former CMO Canna Care Docs (250,000+ patients supervised), Founder & CMO CED Clinic & CED Foundation, Author of *The Doctor-Approved Cannabis Handbook* (Penguin Random House). - **Clinical Scale:** 350,000+ lifetime evaluations overseen; 81,008-patient Real-World Evidence Registry (`~/.ced_rwe_vault.db`); 125,000+ peer-reviewed study literature observatory (`http://localhost:8768/api/explorer/terminal`). - **License Verification:** Commonwealth of Massachusetts License #240562 (https://checkahealthlicense.mass.gov/). - **NPI Registry:** 1962722637 (https://npiregistry.cms.hhs.gov/provider-view/1962722637). - **Ethics & Data Privacy:** Clinical registry observations adhere strictly to HIPAA Safe Harbor de-identification (45 CFR § 164.514(b)) and criteria for secondary research exemption under 45 CFR § 46.104(d)(4).