# Israeli Researchers Present First Clinical Evidence That Cannabis at Microdosing Levels Relieves Pain > **Author:** Benjamin Caplan, MD (ABFM Board Certified, MA Lic. #240562, NPI: 1962722637) > **Publisher:** CED Clinic (https://cedclinic.com) > **Canonical URL:** https://cedclinic.com/cannabis-microdosing-pain-relief-clinical-evidence/ > **Published:** 2020-08-11T13:58:21-04:00 | **Last Modified / Clinically Audited:** 2026-09-28T11:17:26-04:00 > **Clinical Summary:** Discover clinical evidence supporting cannabis microdosing pain relief with precise low-dose THC inhalation for effective pain management without side effects. --- **Syqe Medical’s randomized controlled trial demonstrates for first time that THC doses measured in micrograms relieve pain without significant side effects** In Summary Microdosing – the act of consuming an extremely low dose of an active drug compound to treat various conditions – has been a widely accepted practice throughout the [alternative medicine](https://cedclinic.com/cannabis-based-therapies-smoking-cessation/) and cannabis community for years. Just this year, however, the first clinical trial was conducted to determine the precise dose of the cannabinoid THC that can offer pain relief without the common psychoactive side-effects. Israeli med-tech company [Syqe Medical](https://www.syqemedical.com/) came to the conclusion that just 500 micrograms of THC, consumed via inhalation, is all that is needed for a patient to experience pain relief. For reference, most medical cannabis patients consume up to 150,000 micrograms of THC (by consuming 1 gram of flower with a potency of 15% THC) per day. This news is encouraging for those who are interested in medical cannabis, but are worried about the undesired effects that cannabis can have like anxiety, [appetite stimulation](https://cedclinic.com/dronabinol-hiv-wasting-syndrome-appetite-weight-gain/) and a psychoactive “high” feeling. Syqe has gone so far as to design an inhaler that can measure the precise dose of THC the patient consumes with each application. The device is being marketed by Israel pharmaceutical giant, Teva, with hopes for approvals in Europe and the US in the near future. [LEARN MORE](https://www.prnewswire.com/il/news-releases/israeli-researchers-present-first-clinical-evidence-that-cannabis-at-microdosing-levels-relieves-pain-301086942.html) [https://cedclinic.com/contact/](https://cedclinic.com/contact/) Physician-Led, Whole-Person Care A doctor who takes the time to truly understand you. Personal care that starts with listening and is guided by experience and ingenuity. Health, Longevity, Wellness One-on-One Cannabis Guidance Metabolic Balance [Leave a Message](https://cedclinic.com/contact/) [Metabolic Care](https://cedclinic.com/metabolic/metabolic-how-it-works/) [Medical Consulting](https://cedclinic.com/book/) [Cannabis Care](https://cedclinic.com/book/) [https://cedclinic.com/contact/](https://cedclinic.com/contact/) RELATED READING AT CED CLINIC Continue exploring the evidence [New Study Suggests Cannabinoids May Offer Relief for Chronic Pain Conditions Including …](https://cedclinic.com/new-study-suggests-cannabinoids-may-offer-relief-for-chronic-pain-conditions-including/) Explore recent research highlighting cannabinoids' potential in managing [chronic pain](https://cedclinic.com/cannabinoids-pain-management-opioid-alternative/) conditions effectively. [Read More](https://cedclinic.com/new-study-suggests-cannabinoids-may-offer-relief-for-chronic-pain-conditions-including/) [Non-Intoxicating Cannabinoids Offer Breakthrough Chronic Pain Relief | Streamline](https://cedclinic.com/non-intoxicating-cannabinoids-offer-breakthrough-chronic-pain-relief-streamline/) Learn about non-intoxicating cannabinoids and their promising role in providing [chronic pain relief](https://cedclinic.com/former-nfl-quarterback-urges-athletes-to-consider-cbd-products/) without psychoactive effects. [Discover More](https://cedclinic.com/non-intoxicating-cannabinoids-offer-breakthrough-chronic-pain-relief-streamline/) [Endocannabinoid System Research: Cannabis for Chronic Pain](https://cedclinic.com/cannabinoids-chronic-pain-evidence-review-2025-2/) Understand how cannabis interacts with the [endocannabinoid system](https://cedclinic.com/endocannabinoid-system-fear-extinction/) to alleviate [chronic pain](https://cedclinic.com/cannabinoids-pain-management-opioid-alternative/) symptoms. [Explore Research](https://cedclinic.com/cannabinoids-chronic-pain-evidence-review-2025-2/) Have thoughts on this? Share it: [X Share on X](https://twitter.com/intent/tweet?text=Israeli%20Researchers%20Present%20First%20Clinical%20Evidence%20That%20Cannabis%20at%20Microdosing%20Levels%20Relieves%20Pain&url=https%3A%2F%2Fcedclinic.com%2Fcannabis-microdosing-pain-relief-clinical-evidence%2F) [in Share on LinkedIn](https://www.linkedin.com/sharing/share-offsite/?url=https%3A%2F%2Fcedclinic.com%2Fcannabis-microdosing-pain-relief-clinical-evidence%2F) [Share on BlueSky](https://bsky.app/intent/compose?text=Israeli%20Researchers%20Present%20First%20Clinical%20Evidence%20That%20Cannabis%20at%20Microdosing%20Levels%20Relieves%20Pain%20https%3A%2F%2Fcedclinic.com%2Fcannabis-microdosing-pain-relief-clinical-evidence%2F) [Follow on Instagram](https://www.instagram.com/drbenjamincaplan) [Read more on Substack](https://doctorapprovedcannabis.substack.com/) [Subscribe via RSS](https://cedclinic.com/feed/) ### Related --- ### Verification & Medical Governance - **Lead Clinical Author:** Benjamin Caplan, MD - **Credentials:** Board Certified in Family Medicine (ABFM), Founder & CMO CED Clinic & CED Foundation, Author of *The Doctor-Approved Cannabis Handbook* (Penguin Random House). - **Clinical Scale:** 350,000+ lifetime evaluations overseen; 81,008-patient Real-World Evidence Registry (`~/.ced_rwe_vault.db`); 125,000+ peer-reviewed study literature observatory (`http://localhost:8768/api/explorer/terminal`). - **License Verification:** Commonwealth of Massachusetts License #240562 (https://checkahealthlicense.mass.gov/). - **NPI Registry:** 1962722637 (https://npiregistry.cms.hhs.gov/provider-view/1962722637). - **Ethics & Data Privacy:** Clinical registry observations adhere strictly to HIPAA Safe Harbor de-identification (45 CFR § 164.514(b)) and criteria for secondary research exemption under 45 CFR § 46.104(d)(4).