# Cannabinoid Clinical Trials: Evidence-Based Pediatric Care > **Author:** Benjamin Caplan, MD (ABFM Board Certified, MA Lic. #240562, NPI: 1962722637) > **Publisher:** CED Clinic (https://cedclinic.com) > **Canonical URL:** https://cedclinic.com/cannabinoid-use-pediatric-epilepsy-clinical-trials/ > **Published:** 2026-04-22T23:12:58-04:00 | **Last Modified / Clinically Audited:** 2026-09-28T11:55:26-04:00 > **Clinical Summary:** Explore cannabinoid use in pediatric epilepsy with clinical trial evidence supporting cannabidiol efficacy and safety in childhood seizure disorders. --- #### Clinical Takeaway Current evidence supports cannabinoid use primarily for childhood epilepsy, with FDA-approved cannabidiol showing efficacy in specific seizure disorders. Safety data in pediatric populations remains limited outside epilepsy indications, with most other therapeutic claims based on observational studies lacking rigorous randomized controlled trial evidence. Clinicians should restrict pediatric cannabinoid prescribing to established indications with proven safety profiles and informed consent discussions about evolving evidence. ### #4 Cannabinoids for Medical Purposes in Children: A Living Systematic Review. **Citation:** Chhabra Manik et al. *Cannabinoids for Medical Purposes in Children: A Living [Systematic Review](https://cedclinic.com/cannabinoid-safety-efficacy-mental-health-study/).* Acta paediatrica (Oslo, Norway: 1992). 2025. PMID: 40437694. **Study type:** Journal Article, Systematic Review  |  **Topic area:** Autism  |  **CED Score:** 13 Design: 5 Journal: 0 N: 2 Recency: 2 Pop: 3 Human: 1 Risk: 0 **Methodological Considerations:** - Small sample — underpowered for subgroup analysis **Abstract:** AIM: We developed a living systematic review (LSR) that will continuously map the safety and reported benefit data related to cannabinoid use for medical purposes in children. METHODS: MEDLINE, Embase, PsycInfo, and the Cochrane Library were searched from inception to April 2023. Studies involving at least one child  20% studies) in studies enrolling children were somnolence, diarrhoea, vomiting, and decreased appetite. CONCLUSION: These findings will continue to be updated to inform practice and reveal knowledge gaps for future research.  |   |  [View on PubMed ↗](https://pubmed.ncbi.nlm.nih.gov/40437694/)[Full Text ↗](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336964/)[DOI ↗](https://doi.org/10.1111/apa.70140) [https://cedclinic.com/contact/](https://cedclinic.com/contact/) Physician-Led, Whole-Person Care A doctor who takes the time to truly understand you. Personal care that starts with listening and is guided by experience and ingenuity. Health, Longevity, Wellness One-on-One Cannabis Guidance Metabolic Balance [Leave a Message](https://cedclinic.com/contact/) [Metabolic Care](https://cedclinic.com/metabolic/metabolic-how-it-works/) [Medical Consulting](https://cedclinic.com/book/) [Cannabis Care](https://cedclinic.com/book/) [https://cedclinic.com/contact/](https://cedclinic.com/contact/) RELATED READING AT CED CLINIC Continue exploring the evidence [Medical Cannabis in Pediatrics: Evidence-Based Endocannabinoid Research and Clinical Trials](https://cedclinic.com/cannabinoids-pediatric-medicine-evidence-clinical-trials/) Explore comprehensive research on [medical cannabis](https://cedclinic.com/therapeutic-benefits-of-thc/) use in pediatric care, focusing on [endocannabinoid system](https://cedclinic.com/endocannabinoid-system-fear-extinction/) insights and [clinical trials](https://cedclinic.com/endocannabinoid-system-emotional-memory-ptsd-treatment/). [Read More](https://cedclinic.com/cannabinoids-pediatric-medicine-evidence-clinical-trials/) [Cannabinoids in Pediatric Medicine: Evidence-Based Care and Emerging Research](https://cedclinic.com/cannabinoids-pediatric-clinical-evidence-review/) Review emerging research and evidence-based practices for cannabinoid use in pediatric medicine. [Explore Article](https://cedclinic.com/cannabinoids-pediatric-clinical-evidence-review/) [Endocannabinoid System Research: Cannabinoids in Pediatric Care](https://cedclinic.com/cannabinoid-clinical-trials-pediatric-care-research/) Understand the role of the endocannabinoid system in pediatric care and its implications for cannabinoid therapies. [Learn More](https://cedclinic.com/cannabinoid-clinical-trials-pediatric-care-research/) Have thoughts on this? Share it: [X Share on X](https://twitter.com/intent/tweet?text=Cannabinoid%20Clinical%20Trials%3A%20Evidence-Based%20Pediatric%20Care&url=https%3A%2F%2Fcedclinic.com%2Fcannabinoid-use-pediatric-epilepsy-clinical-trials%2F) [in Share on LinkedIn](https://www.linkedin.com/sharing/share-offsite/?url=https%3A%2F%2Fcedclinic.com%2Fcannabinoid-use-pediatric-epilepsy-clinical-trials%2F) [Share on BlueSky](https://bsky.app/intent/compose?text=Cannabinoid%20Clinical%20Trials%3A%20Evidence-Based%20Pediatric%20Care%20https%3A%2F%2Fcedclinic.com%2Fcannabinoid-use-pediatric-epilepsy-clinical-trials%2F) [Follow on Instagram](https://www.instagram.com/drbenjamincaplan) [Read more on Substack](https://doctorapprovedcannabis.substack.com/) [Subscribe via RSS](https://cedclinic.com/feed/) ### Related --- ### Verification & Medical Governance - **Lead Clinical Author:** Benjamin Caplan, MD - **Credentials:** Board Certified in Family Medicine (ABFM), Founder & CMO CED Clinic & CED Foundation, Author of *The Doctor-Approved Cannabis Handbook* (Penguin Random House). - **Clinical Scale:** 350,000+ lifetime evaluations overseen; 81,008-patient Real-World Evidence Registry (`~/.ced_rwe_vault.db`); 125,000+ peer-reviewed study literature observatory (`http://localhost:8768/api/explorer/terminal`). - **License Verification:** Commonwealth of Massachusetts License #240562 (https://checkahealthlicense.mass.gov/). - **NPI Registry:** 1962722637 (https://npiregistry.cms.hhs.gov/provider-view/1962722637). - **Ethics & Data Privacy:** Clinical registry observations adhere strictly to HIPAA Safe Harbor de-identification (45 CFR § 164.514(b)) and criteria for secondary research exemption under 45 CFR § 46.104(d)(4).