# Cannabinoid Clinical Trials: PTSD and Substance Use > **Author:** Benjamin Caplan, MD (ABFM Board Certified, MA Lic. #240562, NPI: 1962722637) > **Publisher:** CED Clinic (https://cedclinic.com) > **Canonical URL:** https://cedclinic.com/cannabinoid-clinical-trials-ptsd-substance-use/ > **Published:** 2026-03-19T08:58:16-04:00 | **Last Modified / Clinically Audited:** 2026-09-28T11:05:15-04:00 > **Clinical Summary:** Explore cannabinoid clinical trials PTSD substance use findings and their impact on trauma-focused treatments for co-occurring disorders. --- #### Clinical Takeaway People with PTSD and co-occurring substance use disorders who use cannabis can still benefit meaningfully from trauma-focused treatments. [Cannabis use](https://cedclinic.com/cannabis-cardiovascular-health-insights-2024/) does not appear to undermine the effectiveness of evidence-based PTSD therapies in this population. ### #6 Cannabis use and trauma-focused treatment for co-occurring posttraumatic stress disorder and substance use disorders: A meta-analysis of individual patient data. **Citation:** Hill Melanie L et al. *Cannabis use and trauma-focused treatment for co-occurring posttraumatic stress disorder and substance use disorders: A meta-analysis of individual patient data.* Journal of [anxiety disorders](https://cedclinic.com/adolescent-cannabis-use-and-anxiety-research/). 2024. PMID: 38266511. **Study type:** Meta-Analysis, Journal Article, Research Support, N.I.H., Extramural  |  **Topic area:** Anxiety & PTSD  |  **CED Score:** 12 Design: 6 Journal: 0 N: 4 Recency: 1 Pop: 2 Human: 1 Risk: -2 **Quality Gate Alerts:** - Preclinical only **Abstract:** High rates of cannabis use among people with posttraumatic stress disorder (PTSD) have raised questions about the efficacy of evidence-based PTSD treatments for individuals reporting cannabis use, particularly those with co-occurring alcohol or other substance use disorders (SUDs). Using a subset of four randomized [clinical trials](https://cedclinic.com/endocannabinoid-system-emotional-memory-ptsd-treatment/) (RCTs) included in Project Harmony, an individual patient meta-analysis of 36 RCTs (total N = 4046) of treatments for co-occurring PTSD+SUD, we examined differences in trauma-focused (TF) and non-trauma-focused (non-TF) treatment outcomes for individuals who did and did not endorse baseline cannabis use (N = 410; 70% male; 33.2% endorsed cannabis use). Propensity score-weighted mixed effects modeling evaluated main and interactive effects of treatment assignment (TF versus non-TF) and baseline cannabis use (yes/no) on attendance rates and within-treatment changes in PTSD, alcohol, and non-cannabis drug use severity. Results revealed significant improvements across outcomes among participants in all conditions, with larger PTSD symptom reductions but lower attendance among individuals receiving TF versus non-TF treatment in both cannabis groups. Participants achieved similar reductions in alcohol and drug use across all conditions. TF outperformed non-TF treatments regardless of recent cannabis use, underscoring the importance of reducing barriers to accessing TF treatments for individuals reporting cannabis use.  |   |  [View on PubMed ↗](https://pubmed.ncbi.nlm.nih.gov/38266511/)[Full Text ↗](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11138203/)[DOI ↗](https://doi.org/10.1016/j.janxdis.2024.102827) [https://cedclinic.com/contact/](https://cedclinic.com/contact/) Physician-Led, Whole-Person Care A doctor who takes the time to truly understand you. Personal care that starts with listening and is guided by experience and ingenuity. 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[Read More](https://cedclinic.com/trauma-focused-treatment-cannabis-ptsd-sud-meta-analysis/) [Endocannabinoid System Research: Cannabis & PTSD Treatment](https://cedclinic.com/ptsd-cannabis-trauma-meta-analysis/) Research insights into how the [endocannabinoid system](https://cedclinic.com/endocannabinoid-system-fear-extinction/) influences [PTSD treatment](https://cedclinic.com/cannabis-and-ptsd-treatment-memory-loss-benefits/) with cannabis. [Explore Research](https://cedclinic.com/ptsd-cannabis-trauma-meta-analysis/) [Cannabinoid Clinical Trials: PTSD and Substance Use Data](https://cedclinic.com/cannabis-use-trauma-focused-treatment-ptsd-sud-outcomes/) Detailed data from clinical trials examining cannabinoids in PTSD and substance use disorder populations. [View Data](https://cedclinic.com/cannabis-use-trauma-focused-treatment-ptsd-sud-outcomes/) Have thoughts on this? Share it: [X Share on X](https://twitter.com/intent/tweet?text=Cannabinoid%20Clinical%20Trials%3A%20PTSD%20and%20Substance%20Use&url=https%3A%2F%2Fcedclinic.com%2Fcannabinoid-clinical-trials-ptsd-substance-use%2F) [in Share on LinkedIn](https://www.linkedin.com/sharing/share-offsite/?url=https%3A%2F%2Fcedclinic.com%2Fcannabinoid-clinical-trials-ptsd-substance-use%2F) [Share on BlueSky](https://bsky.app/intent/compose?text=Cannabinoid%20Clinical%20Trials%3A%20PTSD%20and%20Substance%20Use%20https%3A%2F%2Fcedclinic.com%2Fcannabinoid-clinical-trials-ptsd-substance-use%2F) [Follow on Instagram](https://www.instagram.com/drbenjamincaplan) [Read more on Substack](https://doctorapprovedcannabis.substack.com/) [Subscribe via RSS](https://cedclinic.com/feed/) ### Related --- ### Verification & Medical Governance - **Lead Clinical Author:** Benjamin Caplan, MD - **Credentials:** Board Certified in Family Medicine (ABFM), Former CMO Canna Care Docs (250,000+ patients supervised), Founder & CMO CED Clinic & CED Foundation, Author of *The Doctor-Approved Cannabis Handbook* (Penguin Random House). - **Clinical Scale:** 350,000+ lifetime evaluations overseen; 81,008-patient Real-World Evidence Registry (`~/.ced_rwe_vault.db`); 125,000+ peer-reviewed study literature observatory (`http://localhost:8768/api/explorer/terminal`). - **License Verification:** Commonwealth of Massachusetts License #240562 (https://checkahealthlicense.mass.gov/). - **NPI Registry:** 1962722637 (https://npiregistry.cms.hhs.gov/provider-view/1962722637). - **Ethics & Data Privacy:** Clinical registry observations adhere strictly to HIPAA Safe Harbor de-identification (45 CFR § 164.514(b)) and criteria for secondary research exemption under 45 CFR § 46.104(d)(4).