# Cannabinoid Clinical Trials: Cannabis Anxiety Relief Study > **Author:** Benjamin Caplan, MD (ABFM Board Certified, MA Lic. #240562, NPI: 1962722637) > **Publisher:** CED Clinic (https://cedclinic.com) > **Canonical URL:** https://cedclinic.com/cannabinoid-clinical-trials-cannabis-anxiety-relief/ > **Published:** 2026-03-18T22:41:26-04:00 | **Last Modified / Clinically Audited:** 2026-09-28T11:05:27-04:00 > **Clinical Summary:** Explore cannabinoid clinical trials cannabis anxiety relief findings showing how THC and CBD impact anxiety differently in flower and edible products. --- #### Clinical Takeaway Cannabis flower and edible products differ in how they affect anxiety on a daily and long-term basis, with product type and cannabinoid composition playing meaningful roles in outcomes. THC and CBD appear to have distinct and sometimes opposing influences on anxiety, making product selection clinically relevant for patients using cannabis to manage anxiety symptoms. ### #8 Therapeutically Motivated Cannabis Use for Anxiety: Daily and Longitudinal Reductions Vary Between Flower and Edible Products. **Citation:** Rosa Luiza et al. *Therapeutically Motivated [Cannabis Use](https://cedclinic.com/cannabis-cardiovascular-health-insights-2024/) for Anxiety: Daily and Longitudinal Reductions Vary Between Flower and Edible Products.* International journal of environmental research and public health. 2026. PMID: 41752306. **Study type:** Journal Article, Randomized Controlled Trial  |  **Topic area:** Cannabidiol  |  **CED Score:** 11 Design: 5 Journal: 0 N: 2 Recency: 3 Pop: 2 Human: 1 Risk: -2 **Quality Gate Alerts:** - Preclinical only **Abstract:** Research shows that delta-9-tetrahydrocannabinol (THC) is linked to increased anxiety, while cannabidiol (CBD) may have anxiolytic effects. Cannabis use is often driven by coping with anxiety, though its daily impact on anxiety remains unclear. This study examined daily associations between cannabis use and anxiety across 30 days in adults who wanted to use cannabis for [anxiety relief](https://cedclinic.com/cannabis-based-medicine-ptsd-anxiety-relief/). Participants (N = 345) used flower or edible products ad libitum and were randomly assigned to groups by product type (CBD, THC, or THC + CBD). Each day, participants reported cannabis use in the past 24 h and rated their anxiety. Linear mixed-effects models tested whether anxiety changed over time, differed by cannabinoid group, and varied with use. Anxiety significantly decreased over the study period in both flower and edibles groups. In the flower group, THC + CBD and [CBD products](https://cedclinic.com/fda-warning-on-cbd-products/) had greater decreases in anxiety (39.5% and 34.8%, respectively) compared to THC products (7.8%). In the edibles group, when participants used CBD products, this was associated with a 24.9% reduction in anxiety over the 30 days. Findings underscore the importance of distinguishing cannabis effects by product type and cannabinoid composition and suggest that CBD-dominant edibles were associated with less anxiety over time in this naturalistic study.  |   |  [View on PubMed ↗](https://pubmed.ncbi.nlm.nih.gov/41752306/)[Full Text ↗](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12941097/)[DOI ↗](https://doi.org/10.3390/ijerph23020224) [https://cedclinic.com/contact/](https://cedclinic.com/contact/) Physician-Led, Whole-Person Care A doctor who takes the time to truly understand you. Personal care that starts with listening and is guided by experience and ingenuity. 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[Read More](https://cedclinic.com/cbd-dominant-cannabis-anxiety-relief-study/) [Endocannabinoid System: Cannabis Reduces Anxiety Long-Term](https://cedclinic.com/cbd-anxiolytic-benefits-anxiety-relief/) Explore long-term anxiety reduction linked to cannabis use and endocannabinoid system regulation. [Explore Study](https://cedclinic.com/cbd-anxiolytic-benefits-anxiety-relief/) [Therapeutically Motivated Cannabis Use for Anxiety](https://cedclinic.com/cannabinoid-pharmacology-anxiety-cannabis-product-effects/) Learn how daily and longitudinal anxiety reductions vary between cannabis flower and edible products. [Discover Insights](https://cedclinic.com/cannabinoid-pharmacology-anxiety-cannabis-product-effects/) Have thoughts on this? Share it: [X Share on X](https://twitter.com/intent/tweet?text=Cannabinoid%20Clinical%20Trials%3A%20Cannabis%20Anxiety%20Relief%20Study&url=https%3A%2F%2Fcedclinic.com%2Fcannabinoid-clinical-trials-cannabis-anxiety-relief%2F) [in Share on LinkedIn](https://www.linkedin.com/sharing/share-offsite/?url=https%3A%2F%2Fcedclinic.com%2Fcannabinoid-clinical-trials-cannabis-anxiety-relief%2F) [Share on BlueSky](https://bsky.app/intent/compose?text=Cannabinoid%20Clinical%20Trials%3A%20Cannabis%20Anxiety%20Relief%20Study%20https%3A%2F%2Fcedclinic.com%2Fcannabinoid-clinical-trials-cannabis-anxiety-relief%2F) [Follow on Instagram](https://www.instagram.com/drbenjamincaplan) [Read more on Substack](https://doctorapprovedcannabis.substack.com/) [Subscribe via RSS](https://cedclinic.com/feed/) ### Related --- ### Verification & Medical Governance - **Lead Clinical Author:** Benjamin Caplan, MD - **Credentials:** Board Certified in Family Medicine (ABFM), Founder & CMO CED Clinic & CED Foundation, Author of *The Doctor-Approved Cannabis Handbook* (Penguin Random House). - **Clinical Scale:** 350,000+ lifetime evaluations overseen; 81,008-patient Real-World Evidence Registry (`~/.ced_rwe_vault.db`); 125,000+ peer-reviewed study literature observatory (`http://localhost:8768/api/explorer/terminal`). - **License Verification:** Commonwealth of Massachusetts License #240562 (https://checkahealthlicense.mass.gov/). - **NPI Registry:** 1962722637 (https://npiregistry.cms.hhs.gov/provider-view/1962722637). - **Ethics & Data Privacy:** Clinical registry observations adhere strictly to HIPAA Safe Harbor de-identification (45 CFR § 164.514(b)) and criteria for secondary research exemption under 45 CFR § 46.104(d)(4).