# Cannabidiol Drug Interactions: Clinical Evidence Review > **Author:** Benjamin Caplan, MD (ABFM Board Certified, MA Lic. #240562, NPI: 1962722637) > **Publisher:** CED Clinic (https://cedclinic.com) > **Canonical URL:** https://cedclinic.com/cannabidiol-drug-interactions-clinical-evidence/ > **Published:** 2026-03-25T21:44:02-04:00 | **Last Modified / Clinically Audited:** 2026-09-28T11:03:43-04:00 > **Clinical Summary:** Explore cannabidiol drug interactions clinical evidence to understand CBD's effects with common medications in cancer care and ensure safe use. --- #### Clinical Takeaway CBD can interact with multiple drug classes commonly used in cancer care, particularly opioids, making careful medication review essential before starting CBD in patients on complex regimens. Clinicians should treat CBD as a pharmacologically active substance subject to the same [drug interaction](https://cedclinic.com/glp-1-addiction-risk-reduction-benefits/) scrutiny as any other medication, not as a benign supplement. ### #17 Drug Interactions in People on Cannabidiol: Is There Cause for Concern? **Citation:** Downs Georgia et al. *[Drug Interactions](https://cedclinic.com/cannabis-liver-interactions-study-insights/) in People on Cannabidiol: Is There Cause for Concern?* Cannabis and [cannabinoid research](https://cedclinic.com/cannabinoids-in-reward-processing-pain-perception/). 2026. PMID: 39539239. **Study type:** Journal Article, Randomized Controlled Trial  |  **Topic area:** Cannabidiol  |  **CED Score:** 10 Design: 5 Journal: 1 N: 0 Recency: 3 Pop: 2 Human: 1 Risk: -2 **Quality Gate Alerts:** - Preclinical only **Abstract:** INTRODUCTION: Cannabidiol (CBD) exhibits multiple therapeutic properties, but its use in advanced cancer patients raises concerns about potential drug-drug interactions (DDIs) due to polypharmacy. This study aims to look for evidence of DDIs between concomitant medications and CBD oil in a randomized placebo-controlled trial of CBD oil for symptom control (MedCan-1 parent study). MATERIALS AND METHODS: Surrogate measures were used to identify possible drug interactions: (1) the maximum mL of oil self-selected by patients in CBD or placebo groups in relation to opioids, specific drug groups, or individual agents; (2) the occurrence of any new or worse adverse effect in relation to the study arm and the concomitant medication classes/medications of interest. RESULTS: The dose of CBD self-selected by participants was not related to opioid use or medications, including benzodiazepines and antipsychotics. The likelihood of developing an adverse effect while on study or when taking specific medications was not increased by CBD. Participants on paracetamol tolerated a higher dose of CBD. DISCUSSION: Concerns regarding the development of clinically significant drug interactions when taking CBD in the context of anti-cancer and other concomitant medications at least in the short term may be unfounded.  |  [View on PubMed ↗](https://pubmed.ncbi.nlm.nih.gov/39539239/)[DOI ↗](https://doi.org/10.1089/can.2024.0041) [https://cedclinic.com/contact/](https://cedclinic.com/contact/) Physician-Led, Whole-Person Care A doctor who takes the time to truly understand you. Personal care that starts with listening and is guided by experience and ingenuity. 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[Explore Article](https://cedclinic.com/cannabinoid-drug-interactions/) [Cannabinoids for Mental & Substance Use Disorders: Evidence](https://cedclinic.com/cannabinoids-for-substance-use-disorders-evidence/) Review of clinical evidence on cannabinoids' role in [mental health](https://cedclinic.com/cannabis-psychiatric-research-findings-depression-anxiety/) and [substance use](https://cedclinic.com/stroke-risk-assessment-substance-use/) disorder treatments. [Learn More](https://cedclinic.com/cannabinoids-for-substance-use-disorders-evidence/) Have thoughts on this? 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