# Enrollees Sought for Trial of Vaccine for C. diff – UW Medicine | Newsroom > **Author:** Benjamin Caplan, MD (ABFM Board Certified, MA Lic. #240562, NPI: 1962722637) > **Publisher:** CED Clinic (https://cedclinic.com) > **Canonical URL:** https://cedclinic.com/c-diff-vaccine-trial-enrollment-uw-medicine/ > **Published:** 2026-04-01T17:04:55-04:00 | **Last Modified / Clinically Audited:** 2026-09-28T17:22:49-04:00 > **Clinical Summary:** Join the C diff vaccine trial at UW Medicine to help prevent Clostridioides difficile infections. Enrollment open for this important clinical study. --- ✦ New CED Clinical Relevance  #80High Clinical Relevance  Strong evidence or policy relevance with direct clinical implications. ⚒ Cannabis News  |  CED Clinic [Infectious Disease](https://cedclinic.com/exchange-transfusion-severe-babesiosis-multicenter-insights/)VaccinationGut Health[Clinical Trials](https://cedclinic.com/endocannabinoid-system-emotional-memory-ptsd-treatment/)Prevention Why This Matters C. diff infections represent a significant clinical challenge with limited prevention options, particularly for high-risk patients including those using cannabis who may have altered gut microbiomes. A preventive vaccine could meaningfully reduce morbidity and healthcare utilization in vulnerable populations. Clinical Summary University of Washington is recruiting participants for a clinical trial of a vaccine against Clostridioides difficile, a hospital-acquired infection that causes severe colitis and carries substantial mortality risk. C. diff infections often occur after antibiotic use disrupts normal gut flora, leading to overgrowth of this toxin-producing bacteria. Current prevention relies primarily on infection control measures and judicious antibiotic use, with treatment options limited to specific antibiotics and fecal microbiota transplantation in severe cases. Dr. Caplan’s Take “This vaccine development is particularly relevant for cannabis patients who may have compromised immune systems or altered gut microbiomes from their underlying conditions. I’ll be watching this trial closely as C. diff prevention could be a game-changer for our most vulnerable patients.” Clinical Perspective 🧠 Clinicians should monitor this vaccine development as it progresses through trials, particularly when caring for immunocompromised patients or those requiring frequent antibiotic courses. Cannabis patients with inflammatory bowel conditions or those using cannabis for gut-related symptoms may represent a population that could benefit significantly from effective C. diff prevention. 💬 Join the Conversation Have a question about how this applies to your situation? [Ask Dr. Caplan →](https://benjamincaplan.com/ask-dr-caplan) Want to discuss this topic with other patients and caregivers? [Join the forum discussion →](https://cedclinic.com/interact/discussion-forums/forum/cannabis-industry/) Have thoughts on this? 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[Learn More](https://cedclinic.com/cell-therapy-parkinsons-disease-motor-symptoms-trial/) [Study: Smoking cannabis does not increase lung cancer risk](https://cedclinic.com/smoking-cannabis-study-washington-state/) Review findings from [Washington State](https://cedclinic.com/cannabis-health-effects-survey-physician-concerns-washington/) University on cannabis smoking and lung cancer risk. [Read Study](https://cedclinic.com/smoking-cannabis-study-washington-state/) University study finds few improvements to at-risk species in B.C. Understand ecological challenges from a recent university study on at-risk species in British Columbia. Explore Research ### Related --- ### Verification & Medical Governance - **Lead Clinical Author:** Benjamin Caplan, MD - **Credentials:** Board Certified in Family Medicine (ABFM), Founder & CMO CED Clinic & CED Foundation, Author of *The Doctor-Approved Cannabis Handbook* (Penguin Random House). - **Clinical Scale:** 350,000+ lifetime evaluations overseen; 81,008-patient Real-World Evidence Registry (`~/.ced_rwe_vault.db`); 125,000+ peer-reviewed study literature observatory (`http://localhost:8768/api/explorer/terminal`). - **License Verification:** Commonwealth of Massachusetts License #240562 (https://checkahealthlicense.mass.gov/). - **NPI Registry:** 1962722637 (https://npiregistry.cms.hhs.gov/provider-view/1962722637). - **Ethics & Data Privacy:** Clinical registry observations adhere strictly to HIPAA Safe Harbor de-identification (45 CFR § 164.514(b)) and criteria for secondary research exemption under 45 CFR § 46.104(d)(4).