# Association of Multimodal Cannabis Use with Adverse Events among Adolescents and Young Adults. > **Author:** Benjamin Caplan, MD (ABFM Board Certified, MA Lic. #240562, NPI: 1962722637) > **Publisher:** CED Clinic (https://cedclinic.com) > **Canonical URL:** https://cedclinic.com/association-of-multimodal-cannabis-use-with-adverse-events-among-adolescent/ > **Published:** 2026-04-28T22:03:13-04:00 | **Last Modified / Clinically Audited:** 2026-09-28T16:05:33-04:00 > **Clinical Summary:** The ways cannabis is consumed, or modes of use, have increased and diversified in recent years, especially among young people. Associations of multimodal can... --- CED Clinical Relevance  #56Monitored Relevance  Early-stage or contextual signal requiring further evidence before action. 🔬 Evidence Watch  |  CED Clinic Journal American journal of preventive medicine Study Type [Clinical Study](https://cedclinic.com/cannabis-hyperemesis-syndrome-psychiatric-risk/) Population Human participants Why This Matters This item covers developments relevant to [cannabis medicine](https://cedclinic.com/essential-oils-industrial-hemp-antimicrobial-benefits/) and [clinical practice](https://cedclinic.com/cannabis-reproductive-health-women-clinical-evidence/). Clinicians monitoring evidence in this area should review the source material. Clinical Summary The ways cannabis is consumed, or modes of use, have increased and diversified in recent years, especially among young people. Associations of multimodal [cannabis use](https://cedclinic.com/cannabis-cardiovascular-health-insights-2024/) (1, 2, or 3+ modes) with adverse events were examined among adolescents and [young adults](https://cedclinic.com/young-adult-substance-use-hidden-brain-costs/). Data from the 2022-2023 National Survey of Drug Use and Health, including non-institutionalized US civilians aged 12-25 reporting past-year [cannabis use](https://cedclinic.com/cannabis-cardiovascular-health-insights-2024/) (n=13,284), were used. Cannabis users were asked about the type (smoking, vaping, dabbing, eating/drinking, and other) and number of cannabis modes used in the past year. Multivariable-adjusted analyses assessed associations of number of modes with adverse events, adjusted for sociodemographic characteristics and frequency of use. Among 51,435 individuals (45.8% adolescents, 51.0% female, 48.1% non-Hispanic white), 13,284 (26.1%) reported past-year cannabis use. Individuals more frequently used 3+ modes (37.5%) than one (34.0%) or two (28.5%), with the most common being smoking (83.9 Dr. Caplan’s Take “This is a development worth tracking. The clinical implications will become clearer as more evidence accumulates.” Clinical Perspective 🧠 Clinicians should review this item in the context of their current practice and patient population. 💬 Join the Conversation Have a question about how this applies to your situation? [Ask Dr. Caplan →](https://benjamincaplan.com/ask-dr-caplan) Want to discuss this topic with other patients and caregivers? [Join the forum discussion →](https://cedclinic.com/interact/discussion-forums/) Have thoughts on this? Share it: [X Share on X](https://twitter.com/intent/tweet?text=Just%20read%20this%20on%20CEDclinic.com%3A%20Association%20of%20Multimodal%20Cannabis%20Use%20with%20Adverse%20Events%20among%20Adolescents%20and%20Young%20Adults.%20%40drcaplan&url=https%3A%2F%2Fcedclinic.com%2Fassociation-of-multimodal-cannabis-use-with-adverse-events-among-adolescent%2F)[in Share on LinkedIn](https://www.linkedin.com/sharing/share-offsite/?url=https%3A%2F%2Fcedclinic.com%2Fassociation-of-multimodal-cannabis-use-with-adverse-events-among-adolescent%2F)[🦅 Share on BlueSky](https://bsky.app/intent/compose?text=Just%20read%20this%3A%20Association%20of%20Multimodal%20Cannabis%20Use%20with%20Adverse%20Events%20among%20Adolescents%20and%20Young%20Adults.%20via%20%40drcaplan.bsky.social%20https%3A%2F%2Fcedclinic.com%2Fassociation-of-multimodal-cannabis-use-with-adverse-events-among-adolescent%2F)[📷 Follow on Instagram](https://www.instagram.com/drbenjamincaplan)[📝 Read more on Substack](https://doctorapprovedcannabis.substack.com/)[🔔 Subscribe via RSS](https://cedclinic.com/feed/) 📰 Source: [https://pubmed.ncbi.nlm.nih.gov/41698445/](https://pubmed.ncbi.nlm.nih.gov/41698445/) Table of Contents - [FAQ](#FAQ)[What data did this study on young cannabis users draw from?](#What_data_did_this_study_on_young_cannabis_users_draw_from) - [What modes of cannabis use did the survey ask about?](#What_modes_of_cannabis_use_did_the_survey_ask_about) - [How many young cannabis users used three or more methods?](#How_many_young_cannabis_users_used_three_or_more_methods) - [Related](#Related) ## FAQ ### What data did this study on young cannabis users draw from? It used the 2022 to 2023 National Survey of Drug Use and Health, covering non-institutionalized U.S. civilians aged 12 to 25. Of 51,435 individuals, 13,284 (26.1%) reported past-year cannabis use. The overall sample was 45.8% adolescents, 51.0% female, and 48.1% non-Hispanic white. ### What modes of cannabis use did the survey ask about? Cannabis users were asked which types of use they had engaged in over the past year, including smoking, vaping, dabbing, eating or drinking, and other methods, and how many different modes they used. The researchers then grouped people by one, two, or three or more modes. ### How many young cannabis users used three or more methods? More than a third. Among young people reporting past-year cannabis use, 37.5% used three or more modes, compared with 34.0% who used one mode and 28.5% who used two. Using three or more modes was the most common pattern, and smoking was the most common mode. 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