# Neuroimaging of Adolescent Cannabis Use Treatment > **Author:** Benjamin Caplan, MD (ABFM Board Certified, MA Lic. #240562, NPI: 1962722637) > **Publisher:** CED Clinic (https://cedclinic.com) > **Canonical URL:** https://cedclinic.com/adolescent-cannabis-use-disorder-treatment-neuroimaging-study/ > **Published:** 2026-05-08T15:07:31-04:00 | **Last Modified / Clinically Audited:** 2026-09-29T00:32:16-04:00 > **Clinical Summary:** New study uses brain imaging to predict which adolescents will respond best to cannabis use disorder treatment programs. --- CED Clinical Relevance  #68Notable Clinical Interest  Emerging findings or policy developments worth monitoring closely. 🧪 Clinical Trial Watch  |  CED Clinic Trial ID NCT07340554 Status Recruiting Condition [Cannabis Use](https://cedclinic.com/cannabis-cardiovascular-health-insights-2024/) Intervention Contingency Management Why This Matters This trial addresses a critical gap in [adolescent cannabis](https://cedclinic.com/cannabis-use-disorder-psychiatric-risk/) treatment by investigating neurobiological predictors of treatment response. Understanding brain-based markers that predict which teens will benefit most from contingency management could enable personalized treatment approaches during this vulnerable developmental period. Clinical Summary This observational study enrolls teens aged 14-17 who use cannabis and employs neuroimaging to examine brain activity patterns related to learning and reward processing. Participants undergo fMRI scanning before entering a 10-week virtual contingency management program that provides incentives for cannabis abstinence, verified through home-based urine testing. The primary endpoint is identifying neural predictors of treatment response, while secondary measures include [cannabis use](https://cedclinic.com/cannabis-cardiovascular-health-insights-2024/) reduction and sustained abstinence rates. Dr. Caplan’s Take “If this research identifies reliable neuroimaging biomarkers, I could potentially use brain-based assessments to guide treatment selection for adolescent patients, moving beyond trial-and-error approaches to more precise, individualized care strategies.” Clinical Perspective 🧠 Families considering participation should understand this involves brain imaging and intensive monitoring but could contribute to breakthrough insights in adolescent [addiction treatment](https://cedclinic.com/cannabis-based-therapies-smoking-cessation/). Clinicians should recognize this represents cutting-edge research into personalized cannabis treatment approaches, though practical clinical applications remain years away. 💬 Join the Conversation Have a question about how this applies to your situation? [Ask Dr. Caplan →](https://benjamincaplan.com/ask-dr-caplan) Want to discuss this topic with other patients and caregivers? [Join the forum discussion →](https://cedclinic.com/interact/discussion-forums/forum/cannabis-industry/) Have thoughts on this? Share it: [𝕏 Share on X](https://twitter.com/intent/tweet?text=Just%20read%20this%20on%20CEDclinic.com%3A%20Neuroimaging%20of%20Adolescent%20Cannabis%20Use%20Treatment%20%40drcaplan&url=https%3A//clinicaltrials.gov/study/NCT07340554)[in Share on LinkedIn](https://www.linkedin.com/sharing/share-offsite/?url=https%3A//clinicaltrials.gov/study/NCT07340554)[🦥 Share on BlueSky](https://bsky.app/intent/compose?text=Just%20read%20this%3A%20Neuroimaging%20of%20Adolescent%20Cannabis%20Use%20Treatment%20--%20via%20%40drcaplan.bsky.social%20https%3A//clinicaltrials.gov/study/NCT07340554)[📷 Follow on Instagram](https://www.instagram.com/drbenjamincaplan/)[📝 Read more on Substack](https://substack.com/@doctorapproved)[🔔 Subscribe via RSS](https://cedclinic.com/category/cannabis-news/feed/) 📰 Source: [https://clinicaltrials.gov/study/NCT07340554](https://clinicaltrials.gov/study/NCT07340554) Table of Contents - [FAQ](#FAQ)[What do the brain scans in this adolescent cannabis trial examine?](#What_do_the_brain_scans_in_this_adolescent_cannabis_trial_examine) - [Who can take part in this adolescent cannabis treatment study?](#Who_can_take_part_in_this_adolescent_cannabis_treatment_study) - [What is the contingency management program in this trial?](#What_is_the_contingency_management_program_in_this_trial) - [What outcomes will this adolescent cannabis trial measure?](#What_outcomes_will_this_adolescent_cannabis_trial_measure) - [Related](#Related) ## FAQ ### What do the brain scans in this adolescent cannabis trial examine? Participants undergo fMRI scanning, a type of neuroimaging, before entering the treatment program. The scans examine brain activity patterns related to learning and reward processing. These scans allow researchers to look for brain-based patterns linked to how each teen later responds to treatment. ### Who can take part in this adolescent cannabis treatment study? The study enrolls teens aged 14 to 17 who use cannabis. It is an observational study registered as NCT07340554 and is listed as recruiting. The summary does not describe other eligibility requirements beyond age and cannabis use. ### What is the contingency management program in this trial? It is a 10-week virtual program that provides incentives for cannabis abstinence. Abstinence is verified through home-based urine testing. Teens enter the program after completing fMRI scanning, so researchers can later compare their brain activity with how they respond to treatment. ### What outcomes will this adolescent cannabis trial measure? The primary endpoint is identifying neural predictors of treatment response. Secondary measures include reduction in cannabis use and rates of sustained abstinence. Together, these outcomes connect the brain imaging findings to how well teens do in the contingency management program. [https://cedclinic.com/contact/](https://cedclinic.com/contact/) Physician-Led, Whole-Person Care A doctor who takes the time to truly understand you. Personal care that starts with listening and is guided by experience and ingenuity. Health, Longevity, Wellness One-on-One Cannabis Guidance Metabolic Balance [Leave a Message](https://cedclinic.com/contact/) [Metabolic Care](https://cedclinic.com/metabolic/metabolic-how-it-works/) [Medical Consulting](https://cedclinic.com/book/) [Cannabis Care](https://cedclinic.com/book/) [https://cedclinic.com/contact/](https://cedclinic.com/contact/) ### Related --- ### Verification & Medical Governance - **Lead Clinical Author:** Benjamin Caplan, MD - **Credentials:** Board Certified in Family Medicine (ABFM), Founder & CMO CED Clinic & CED Foundation, Author of *The Doctor-Approved Cannabis Handbook* (Penguin Random House). - **Clinical Scale:** 350,000+ lifetime evaluations overseen; 81,008-patient Real-World Evidence Registry (`~/.ced_rwe_vault.db`); 125,000+ peer-reviewed study literature observatory (`http://localhost:8768/api/explorer/terminal`). - **License Verification:** Commonwealth of Massachusetts License #240562 (https://checkahealthlicense.mass.gov/). - **NPI Registry:** 1962722637 (https://npiregistry.cms.hhs.gov/provider-view/1962722637). - **Ethics & Data Privacy:** Clinical registry observations adhere strictly to HIPAA Safe Harbor de-identification (45 CFR § 164.514(b)) and criteria for secondary research exemption under 45 CFR § 46.104(d)(4).