# Accidental Ingestion of Cannabis in Two Infants and a Preschool Child: Case Reports and Literature Review > **Author:** Benjamin Caplan, MD (ABFM Board Certified, MA Lic. #240562, NPI: 1962722637) > **Publisher:** CED Clinic (https://cedclinic.com) > **Canonical URL:** https://cedclinic.com/acute-pediatric-cannabis-intoxication-case-reports/ > **Published:** 2026-03-26T08:05:48-04:00 | **Last Modified / Clinically Audited:** 2026-09-28T10:38:12-04:00 > **Clinical Summary:** Explore acute pediatric cannabis intoxication with case reports from Tunisia highlighting severe CNS depression in infants after accidental ingestion. --- CED Clinical Relevance  #61Notable Clinical Interest  Emerging findings or policy developments worth monitoring closely. 🔬 Evidence Watch  |  CED Clinic PediatricToxicologyThcCns DepressionCase Series Journal La Tunisie medicale Study Type [Clinical Study](https://cedclinic.com/cannabis-hyperemesis-syndrome-psychiatric-risk/) Population Human participants Why This Matters [Pediatric cannabis](https://cedclinic.com/cannabis-for-childrens-behavior/) exposures are increasing globally as access expands, and infants show markedly different toxicity profiles than adults. This case series from Tunisia documents severe neurologic depression requiring intensive care, highlighting the critical need for secure storage and clinical awareness. Clinical Summary Three Tunisian infants aged 7-30 months presented with accidental cannabis ingestion over one year. Two developed significant drowsiness while one required mechanical ventilation for coma. All had positive urine cannabinoid screens and recovered with [supportive care](https://cedclinic.com/pediatric-oncology-supportive-care-cannabis-research-funding-iowa/). The study represents the first reported [pediatric cannabis](https://cedclinic.com/cannabis-for-childrens-behavior/) toxicity cases from Tunisia, where cannabis remains illegal but consumption is rising. Dr. Caplan’s Take “These cases reinforce what we know clinically – cannabis affects children very differently than adults, with potential for serious CNS depression even from small exposures. The severity requiring mechanical ventilation in a 30-month-old underscores that pediatric cannabis toxicity is not benign.” Clinical Perspective 🧠 Clinicians should maintain high suspicion for cannabis exposure in pediatric patients with unexplained altered mental status. [Patient education](https://cedclinic.com/medical-cannabis-patient-education-basics/) about secure storage remains paramount, and [urine drug screening](https://cedclinic.com/biologic-matrices-cannabis-indicators-review-2006/) should be considered in appropriate clinical contexts even in jurisdictions where cannabis is prohibited. 💬 Join the Conversation Have a question about how this applies to your situation? [Ask Dr. Caplan →](https://benjamincaplan.com/ask-dr-caplan) Want to discuss this topic with other patients and caregivers? [Join the forum discussion →](https://cedclinic.com/interact/discussion-forums/forum/cannabis-industry/) Have thoughts on this? Share it: [𝕏 Share on X](https://twitter.com/intent/tweet?text=Just%20read%20this%20on%20CEDclinic.com%3A%20Accidental%20ingestion%20of%20cannabis%20in%20two%20infants%20and%20a%20preschool%20child%20reported%20b...%20%40drcaplan&url=https%3A//pubmed.ncbi.nlm.nih.gov/41712840/)[in Share on LinkedIn](https://www.linkedin.com/sharing/share-offsite/?url=https%3A//pubmed.ncbi.nlm.nih.gov/41712840/)[🦥 Share on BlueSky](https://bsky.app/intent/compose?text=Just%20read%20this%3A%20Accidental%20ingestion%20of%20cannabis%20in%20two%20infants%20and%20a%20preschool%20child%20reported%20b...%20--%20via%20%40drcaplan.bsky.social%20https%3A//pubmed.ncbi.nlm.nih.gov/41712840/)[📷 Follow on Instagram](https://www.instagram.com/drbenjamincaplan/)[📝 Read more on Substack](https://substack.com/@doctorapproved)[🔔 Subscribe via RSS](https://cedclinic.com/category/cannabis-news/feed/) 📰 Source: [https://pubmed.ncbi.nlm.nih.gov/41712840/](https://pubmed.ncbi.nlm.nih.gov/41712840/) Table of Contents - [FAQ](#FAQ)[How does cannabis ingestion affect infants and young children compared to adults?](#How_does_cannabis_ingestion_affect_infants_and_young_children_compared_to_adults) - [What are the typical clinical presentations of accidental cannabis ingestion in pediatric patients?](#What_are_the_typical_clinical_presentations_of_accidental_cannabis_ingestion_in_pediatric_patients) - [How should healthcare providers manage pediatric cannabis intoxication?](#How_should_healthcare_providers_manage_pediatric_cannabis_intoxication) - [What diagnostic tests are useful for confirming cannabis ingestion in children?](#What_diagnostic_tests_are_useful_for_confirming_cannabis_ingestion_in_children) - [What is the prognosis for children who accidentally ingest cannabis?](#What_is_the_prognosis_for_children_who_accidentally_ingest_cannabis) - [Related](#Related) ## FAQ #### How does cannabis ingestion affect infants and young children compared to adults? Unlike adults who typically remain asymptomatic after cannabis ingestion, infants and preschool children can develop severe neurological symptoms including drowsiness and coma. This case series demonstrates that children aged 7-30 months experienced significant CNS depression, with one requiring mechanical ventilation. #### What are the typical clinical presentations of accidental cannabis ingestion in pediatric patients? Based on these cases, children may present with altered mental status ranging from drowsiness to coma requiring respiratory support. All patients had positive urinary drug screens for cannabis, confirming the diagnosis in cases of suspected accidental ingestion. #### How should healthcare providers manage pediatric cannabis intoxication? Management focuses on [supportive care](https://cedclinic.com/pediatric-oncology-supportive-care-cannabis-research-funding-iowa/) including surveillance and stabilization of vital functions. Severe cases may require mechanical ventilation for respiratory depression, as demonstrated by the comatose 30-month-old patient in this series. #### What diagnostic tests are useful for confirming cannabis ingestion in children? Urinary drug screening for cannabis metabolites is the primary diagnostic tool, as demonstrated in all three cases where positive results confirmed suspected accidental ingestion. This testing is particularly valuable when the ingestion history is unclear or uncertain. #### What is the prognosis for children who accidentally ingest cannabis? The prognosis appears favorable with appropriate supportive care, as all three patients in this series were successfully discharged after surveillance and stabilization. However, close monitoring is essential given the potential for severe CNS depression in this vulnerable population. {“@context”: “https://schema.org”, “@type”: “ScholarlyArticle”, “headline”: “Accidental ingestion of cannabis in two infants and a preschool child reported by the Tunisian poison control center: Three case reports and review of literature.”, “url”: “https://pubmed.ncbi.nlm.nih.gov/41712840/”, “about”: “la tunisie medicale [clinical study](https://cedclinic.com/cannabis-hyperemesis-syndrome-psychiatric-risk/) accidental”, “isPartOf”: “La Tunisie medicale”} [https://cedclinic.com/contact/](https://cedclinic.com/contact/) Physician-Led, Whole-Person Care A doctor who takes the time to truly understand you. Personal care that starts with listening and is guided by experience and ingenuity. 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Explore Details ### Related --- ### Verification & Medical Governance - **Lead Clinical Author:** Benjamin Caplan, MD - **Credentials:** Board Certified in Family Medicine (ABFM), Founder & CMO CED Clinic & CED Foundation, Author of *The Doctor-Approved Cannabis Handbook* (Penguin Random House). - **Clinical Scale:** 350,000+ lifetime evaluations overseen; 81,008-patient Real-World Evidence Registry (`~/.ced_rwe_vault.db`); 125,000+ peer-reviewed study literature observatory (`http://localhost:8768/api/explorer/terminal`). - **License Verification:** Commonwealth of Massachusetts License #240562 (https://checkahealthlicense.mass.gov/). - **NPI Registry:** 1962722637 (https://npiregistry.cms.hhs.gov/provider-view/1962722637). - **Ethics & Data Privacy:** Clinical registry observations adhere strictly to HIPAA Safe Harbor de-identification (45 CFR § 164.514(b)) and criteria for secondary research exemption under 45 CFR § 46.104(d)(4).